Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4926 VK055_4222 putative membrane fusion protein of efflux pump AlphaFold DB model + ColabFold model – – No map 0.009 0.43 No Hit 0.0% —
4927 VK055_4052 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.009 0.728 No Hit 0.0% —
4928 VK055_3976 cob(I)alamin adenosyltransferase AlphaFold DB model + ColabFold model
2.5.1.17
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008817Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
Chokepoint 7 0.009 0.507 Hit 51.2% 9.18e-06
4929 VK055_3690 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.009 0.348 No Hit 0.0% —
4930 VK055_3373 small heat shock protein IbpA ibpA AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050821Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
No map 0.009 0.401 No Hit 0.0% —
4931 VK055_2160 ubiquinol oxidase, subunit II cyoA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005507Binding to a copper (Cu) ion. GO:0009486Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]. +58 total
No map 0.009 0.451 No Hit 0.0% —
4932 VK055_1827 ybfN-like lipofamily protein AlphaFold DB model + ColabFold model – – No map N/A 0.009 No Hit 0.0% —
4933 VK055_1401 hypothetical protein ColabFold model – – No map 0.009 0.91 No Hit 0.0% —
4934 VK055_1261 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.009 0.375 No Hit 0.0% —
4935 VK055_0701 putative polysaccharide deacetylase ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.009 0.055 No Hit 0.0% —
4936 VK055_0405 isochorismatase family protein AlphaFold DB model + ColabFold model – – No map 0.009 0.538 No Hit 0.0% —
4937 VK055_4961 response regulator AlphaFold DB model + ColabFold model –
GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
No map 0.008 0.504 No Hit 0.0% —
4938 VK055_4640 scaffold protein involved in iron-sulfur cluster assembly AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005506Binding to an iron (Fe) ion. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
No map 0.008 0.181 Hit 75.4% 2.18e-69
4939 VK055_4513 glutaredoxin family protein AlphaFold DB model + ColabFold model – – No map 0.008 0.497 No Hit 0.0% —
4940 VK055_4306 BMC domain protein ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.008 0.652 No Hit 0.0% —
4941 VK055_4131 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.008 0.494 No Hit 0.0% —
4942 VK055_3381 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.008 0.714 No Hit 0.0% —
4943 VK055_2967 phosphonate C-P lyase system protein PhnG phnG AlphaFold DB model + ColabFold model –
GO:0019634The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. GO:0015716The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Chokepoint 3 0.008 0.64 No Hit 0.0% —
4944 VK055_2886 nsrR nsrR AlphaFold DB model + ColabFold model –
GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. +36 total
No map 0.008 0.227 No Hit 0.0% —
4945 VK055_2413 type II secretion system protein I gspI AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.008 0.611 No Hit 0.0% —
4946 VK055_1816 K+-transporting ATPase, C subunit kdpC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006813The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008556Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). +25 total
No map 0.008 0.485 No Hit 0.0% —
4947 VK055_0575 putative lipoprotein AlphaFold DB model + ColabFold model – – No map N/A 0.008 No Hit 0.0% —
4948 VK055_5099 bacterial regulatory, luxR family protein ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.007 0.127 No Hit 0.0% —
4949 VK055_4813 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.007 0.759 No Hit 0.0% —
4950 VK055_4091 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.007 0.184 Hit 34.2% 5.93e-11
Page of 204 · 5081 total proteins