Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4826 VK055_3869 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase yrbI Experimental + ColabFold model
3.1.3.45
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0019143Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate. GO:0046872Binding to a metal ion. +25 total
Chokepoint 1 0.021 0.287 Hit 32.3% 1.02e-18
4827 VK055_1363 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0031241The leaflet of a outer cell membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +14 total
No map 0.021 0.579 No Hit 0.0% —
4828 VK055_0487 lactoylglutathione lyase gloA AlphaFold DB model + ColabFold model
4.4.1.5
GO:0004462Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. GO:0046872Binding to a metal ion. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
Chokepoint 2 0.021 0.282 Hit 36.3% 1.01e-24
4829 VK055_5060 malonate semialdehyde decarboxylase msaD AlphaFold DB model + ColabFold model – – No map 0.020 0.15 No Hit 0.0% —
4830 VK055_5015 putative outer membrane lipoprotein Wza wza AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015159Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0015774The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. +47 total
No map 0.020 0.714 No Hit 0.0% —
4831 VK055_4609 ribonuclease III rnc AlphaFold DB model + ColabFold model
3.1.26.3
GO:0004525Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +912 total
No map 0.020 0.374 Hit 35.1% 9.48e-07
4832 VK055_3789 ogr/Delta-like zinc finger family protein AlphaFold DB model + ColabFold model –
GO:0003917Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. +25 total
No map 0.020 0.767 No Hit 0.0% —
4833 VK055_3393 uhpA transcriptional activator uhpA AlphaFold DB model + ColabFold model –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.020 0.205 No Hit 0.0% —
4834 VK055_2431 PTS system fructose IIA component family protein AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.020 0.204 No Hit 0.0% —
4835 VK055_1122 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0019825Binding to oxygen (O2). GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
No map 0.020 0.387 No Hit 0.0% —
4836 VK055_0857 bacterial regulatory helix-turn-helix, lysR family protein Experimental + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.020 0.331 No Hit 0.0% —
4837 VK055_0525 metal-sensitive transcriptional repressor familyprotein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0046872Binding to a metal ion. +14 total
No map N/A 0.02 No Hit 0.0% —
4838 VK055_0510 electron transport complex, RnfABCDGE type, G subunit AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. +25 total
No map 0.020 0.296 No Hit 0.0% —
4839 VK055_5024 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.019 0.494 No Hit 0.0% —
4840 VK055_4698 gcvR GcvR predicted transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.019 0.473 No Hit 0.0% —
4841 VK055_4568 ribosomal protein S16 rpsP AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +25 total
No map 0.019 0.301 Hit 42.7% 3.80e-18
4842 VK055_4157 flavinator of succinate dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0034552The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II. GO:0006105The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.
No map 0.019 0.752 No Hit 0.0% —
4843 VK055_4035 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.019 0.516 No Hit 0.0% —
4844 VK055_3921 BON domain protein AlphaFold DB model + ColabFold model – – No map 0.019 0.442 No Hit 0.0% —
4845 VK055_3918 putative uPF0306 protein yhbP AlphaFold DB model + ColabFold model – – No map 0.019 0.426 No Hit 0.0% —
4846 VK055_3711 cell division protein DamX damX AlphaFold DB model + ColabFold model –
GO:0032506A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). GO:0030428A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
No map 0.019 0.103 No Hit 0.0% —
4847 VK055_1443 nitroreductase family protein AlphaFold DB model + ColabFold model
1.1.1.298
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0035527Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH. GO:0019740A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism. +14 total
No map 0.019 0.566 No Hit 0.0% —
4848 VK055_1003 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.019 No Hit 0.0% —
4849 VK055_0870 marR family protein marR AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.019 0.755 No Hit 0.0% —
4850 VK055_5186 hypothetical protein ColabFold model – – No map 0.018 0.618 No Hit 0.0% —
Page of 204 · 5081 total proteins