Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4826 VK055_0418 hypothetical protein AlphaFold + ColabFold –
GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
0.102 No Hit 0.0% —
4827 VK055_0357 hypothetical protein ColabFold – – 0.102 No Hit 0.0% —
4828 VK055_5177 hypothetical protein AlphaFold + ColabFold – – 0.101 No Hit 0.0% —
4829 VK055_1884 dsbGreduced AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.101 No Hit 0.0% —
4830 VK055_0451 putative inner membrane protein AlphaFold + ColabFold – – 0.101 No Hit 0.0% —
4831 VK055_5067 hypothetical protein AlphaFold + ColabFold – – 0.1 No Hit 0.0% —
4832 VK055_2314 crl transcriptional regulator AlphaFold + ColabFold –
GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.1 No Hit 0.0% —
4833 VK055_2284 putative transcriptional regulator ColabFold – – 0.1 No Hit 0.0% —
4834 VK055_2966 phosphonate metabolism transcriptional regulatorPhnF phnF AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.099 No Hit 0.0% —
4835 VK055_4645 feS assembly protein IscX iscX AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
0.098 No Hit 0.0% —
4836 VK055_2263 putative receptor AlphaFold + ColabFold – – 0.098 No Hit 0.0% —
4837 VK055_4638 iscR transcriptional regulator IscR transcriptional dual regulator iscR AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.096 No Hit 0.0% —
4838 VK055_3924 putative glycosylase AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +47 total
0.096 No Hit 0.0% —
4839 VK055_3278 branched-chain amino acid transport family protein AlphaFold + ColabFold – – 0.096 No Hit 0.0% —
4840 VK055_3253 regulator of ribonuclease activity A rraA AlphaFold + ColabFold –
GO:0008428Binds to and stops, prevents or reduces the activity of ribonuclease. GO:0051252Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
0.096 No Hit 0.0% —
4841 VK055_1487 acylphosphatase acyP AlphaFold + ColabFold
3.6.1.7
GO:0003998Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.
0.096 Hit 35.4% 2.51e-08
4842 VK055_0907 hypothetical protein AlphaFold + ColabFold –
GO:0003697Binding to single-stranded DNA. GO:0018142OBSOLETE. The formation of a covalent cross-link between DNA and a protein. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
0.096 Hit 33.3% 5.13e-07
4843 VK055_0890 hypothetical protein AlphaFold + ColabFold – – 0.096 No Hit 0.0% —
4844 VK055_3095 uroporphyrinogen decarboxylase hemE AlphaFold + ColabFold
4.1.1.37
GO:0004853Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. GO:0006779The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.095 Hit 70.2% 4.41e-21
4845 VK055_0461 carbonate dehydratase carbonic anhydrase cynT AlphaFold + ColabFold
4.2.1.1
GO:0008270Binding to a zinc ion (Zn). GO:0015976A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. GO:0004089Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O.
0.095 No Hit 0.0% —
4846 VK055_3359 chromosomal replication initiator protein DnaA dnaA AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +710 total
0.094 No Hit 0.0% —
4847 VK055_2997 fimbrial family protein AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.094 No Hit 0.0% —
4848 VK055_1564 lrp transcriptional dual regulator lrp AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006524OBSOLETE. The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid. +25 total
0.094 No Hit 0.0% —
4849 VK055_2760 phage integrase family protein AlphaFold + ColabFold –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
0.093 No Hit 0.0% —
4850 VK055_0638 30S ribosomal subunit S22 family protein AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
0.09 No Hit 0.0% —
Page of 204 · 5081 total proteins