Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2326 VK055_0181 hypothetical protein AlphaFold + ColabFold – – 0.605 No Hit 0.0% —
2327 VK055_0126 putative peptidase AlphaFold + ColabFold –
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.605 No Hit 0.0% —
2328 VK055_4994 peptidase U32 family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +14 total
0.604 No Hit 0.0% —
2329 VK055_4664 hypothetical protein AlphaFold + ColabFold – – 0.604 No Hit 0.0% —
2330 VK055_4318 propanediol dehydratase small subunit pduE AlphaFold + ColabFold – – 0.604 No Hit 0.0% —
2331 VK055_3369 galactonate dehydratase dgoD AlphaFold + ColabFold
4.2.1.6
GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0008869Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O. GO:0034194The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid. +14 total
0.604 Hit 25.8% 3.22e-10
2332 VK055_2757 hypothetical protein ColabFold – – 0.604 No Hit 0.0% —
2333 VK055_2742 PLD-like domain protein ColabFold – – 0.604 No Hit 0.0% —
2334 VK055_4188 bacterial extracellular solute-binding, 5 Middlefamily protein AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.603 No Hit 0.0% —
2335 VK055_3884 obg family GTPase CgtA cgtA AlphaFold + ColabFold
3.6.5.-
GO:0005525Binding to GTP, guanosine triphosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. +47 total
0.603 Hit 44.2% 5.00e-17
2336 VK055_2790 putative ATPase AlphaFold + ColabFold – – 0.603 No Hit 0.0% —
2337 VK055_0148 tonB-dependent siderophore receptor family protein AlphaFold + ColabFold –
GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). GO:0038023Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +25 total
0.603 No Hit 0.0% —
2338 VK055_3646 tryptophan/tyrosine permease family protein AlphaFold + ColabFold –
GO:0003333The process in which an amino acid is transported across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.602 No Hit 0.0% —
2339 VK055_3583 cellulose biosynthesis protein BcsE bcsE AlphaFold + ColabFold –
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
0.602 No Hit 0.0% —
2340 VK055_2509 thiamine ABC transporter, ATP-binding protein thiQ AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. +25 total
0.602 Hit 34.9% 1.24e-20
2341 VK055_1145 hypothetical protein AlphaFold + ColabFold – – 0.602 No Hit 0.0% —
2342 VK055_0456 bacterial extracellular solute-binding, 5 Middlefamily protein AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
0.602 No Hit 0.0% —
2343 VK055_4685 phosphoribosylglycinamide formyltransferase purN AlphaFold + ColabFold
2.1.2.2
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0004644Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. +14 total
0.601 Hit 44.0% 1.32e-35
2344 VK055_2267 bacterial regulatory, luxR family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.601 No Hit 0.0% —
2345 VK055_1068 amino acid permease family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.601 Hit 25.2% 1.15e-07
2346 VK055_0060 yecM family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.601 No Hit 0.0% —
2347 VK055_4090 non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family rdgB AlphaFold + ColabFold
3.6.1.66
GO:0009143The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. GO:0047429Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. GO:0017111Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. +811 total
0.6 Hit 31.6% 2.82e-13
2348 VK055_3780 hypothetical protein AlphaFold + ColabFold – – 0.6 No Hit 0.0% —
2349 VK055_3277 azlC family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1903785The directed movement of L-valine across a membrane.
0.6 No Hit 0.0% —
2350 VK055_2876 ulaB sgaB AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
0.6 No Hit 0.0% —
Page of 204 · 5081 total proteins