Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2376 VK055_1823 lexA-regulated protein ybfE AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map N/A 0.591 No Hit 0.0% —
2377 VK055_1573 cold shock domain protein CspD cspD AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
No map N/A 0.591 Hit 40.3% 4.45e-07
2378 VK055_1129 hypothetical protein ColabFold model – – No map N/A 0.591 No Hit 0.0% —
2379 VK055_3399 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.59 No Hit 0.0% —
2380 VK055_5066 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.589 0.513 No Hit 0.0% —
2381 VK055_2195 secD secD AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +69 total
No map 0.589 0.962 No Hit 0.0% —
2382 VK055_4756 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.588 No Hit 0.0% —
2383 VK055_4150 cytochrome C biogenesis transmembrane region family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. +14 total
No map 0.588 0.999 No Hit 0.0% —
2384 VK055_4082 A/G-specific adenine glycosylase mutY AlphaFold DB model + ColabFold model
3.2.2.31
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019104Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. +1013 total
No map 0.588 0.477 Hit 44.9% 2.34e-56
2385 VK055_4053 dienelactone hydrolase family protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.588 0.441 Hit 26.6% 4.68e-10
2386 VK055_4032 flavodoxin-like fold family protein AlphaFold DB model + ColabFold model
1.6.5.10
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008753Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol.
No map 0.588 0.586 No Hit 0.0% —
2387 VK055_2820 addiction module toxin, RelE/StbE family protein AlphaFold DB model + ColabFold model – – No map N/A 0.588 No Hit 0.0% —
2388 VK055_1399 lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase family protein lpxL2 AlphaFold DB model + ColabFold model
2.3.1.241
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +47 total
No map 0.588 0.736 No Hit 0.0% —
2389 VK055_2240 porphobilinogen synthase hemB AlphaFold DB model + ColabFold model
4.2.1.24
GO:0004655Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0046872Binding to a metal ion. +36 total
Chokepoint 1 0.587 0.454 Hit 42.4% 3.93e-76
2390 VK055_4529 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.586 No Hit 0.0% —
2391 VK055_0975 universal stress protein with a role in resistance to UV irradiation ydaA AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.586 0.311 No Hit 0.0% —
2392 VK055_0100 conserved inner membrane protein yebS AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009061The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.
No map 0.586 0.702 No Hit 0.0% —
2393 VK055_3562 3-methyladenine DNA glycosylase I tag AlphaFold DB model + ColabFold model
3.2.2.20
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. +25 total
No map 0.585 0.248 No Hit 0.0% —
2394 VK055_1383 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.585 0.945 No Hit 0.0% —
2395 VK055_4201 emrA Membrane Fusion Protein AlphaFold DB model + ColabFold model –
GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map N/A 0.584 No Hit 0.0% —
2396 VK055_2879 esterase yjfP Experimental + ColabFold model
3.1.1.23
GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0047372Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+.
No map 0.584 0.433 No Hit 0.0% —
2397 VK055_1946 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+. GO:0016034Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. GO:0006749The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. +14 total
No map 0.584 0.559 Hit 29.5% 1.09e-06
2398 VK055_1147 peripheral inner membrane phage-shock protein pspD AlphaFold DB model + ColabFold model – – No map N/A 0.584 No Hit 0.0% —
2399 VK055_0103 tail-specific protease AlphaFold DB model + ColabFold model
3.4.21.102
GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. +47 total
No map 0.584 0.168 No Hit 0.0% —
2400 VK055_4585 ATP-dependent chaperone protein ClpB clpB AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0042026The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +36 total
No map 0.583 0.698 Hit 42.3% 6.53e-54
Page of 204 · 5081 total proteins