Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2351 VK055_0344 4-hydroxy-2-oxovalerate aldolase dmpG AlphaFold DB model + ColabFold model
4.1.3.39
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. GO:0008701Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. +58 total
Mapped 1 0.600 0.032 Hit 26.5% 3.24e-07
2352 VK055_0001 lambda phage tail tape-measure family protein ColabFold model – – No map N/A 0.6 No Hit 0.0% —
2353 VK055_1725 HAMP domain protein AlphaFold DB model + ColabFold model
2.7.13.3
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +36 total
No map 0.599 0.123 No Hit 0.0% —
2354 VK055_1287 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.599 0.862 No Hit 0.0% —
2355 VK055_0766 helix-turn-helix family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.599 0.518 No Hit 0.0% —
2356 VK055_4448 hydrogenase expression/formation protein HypD hypD AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0070025Binding to carbon monoxide (CO). +25 total
No map 0.598 0.748 No Hit 0.0% —
2357 VK055_3892 preprotein translocase, SecG subunit secG ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015450Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.
No map N/A 0.598 No Hit 0.0% —
2358 VK055_3862 putative P-loop containing ATPase AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003723Binding to an RNA molecule or a portion thereof.
No map 0.598 0.484 No Hit 0.0% —
2359 VK055_2741 lon protease (S16) C-terminal proteolytic domainprotein AlphaFold DB model + ColabFold model
3.4.21.53
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004176Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. +25 total
No map 0.598 0.62 No Hit 0.0% —
2360 VK055_0894 putative tRNA synthase AlphaFold DB model + ColabFold model
2.7.1.217
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
No map 0.597 0.637 No Hit 0.0% —
2361 VK055_2420 ATP-dependent helicase HrpB hrpB AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. +14 total
No map 0.596 0.159 Hit 40.8% 5.56e-19
2362 VK055_2396 glutamate-1-semialdehyde-2,1-aminomutase hemL AlphaFold DB model + ColabFold model
5.4.3.8
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0042286Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +47 total
Chokepoint 1 0.596 0.722 Hit 29.2% 1.73e-25
2363 VK055_0221 chaA calcium CaCA transporter AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.596 0.775 No Hit 0.0% —
2364 VK055_2755 hypothetical protein ColabFold model – – No map 0.595 0.494 Hit 39.2% 1.96e-06
2365 VK055_1084 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.595 0.549 No Hit 0.0% —
2366 VK055_3262 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
No map 0.594 0.689 No Hit 0.0% —
2367 VK055_1824 flavodoxin AlphaFold DB model + ColabFold model –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
No map 0.594 0.386 No Hit 0.0% —
2368 VK055_1611 aspT/YidE/YbjL antiporter duplication domain protein AlphaFold DB model + ColabFold model –
GO:0006813The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008324Enables the transfer of cation from one side of a membrane to the other.
No map 0.594 0.911 No Hit 0.0% —
2369 VK055_4022 catalytic LigB subunit of aromatic ring-opening dioxygenase family protein AlphaFold DB model + ColabFold model
1.13.11.29
GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016701Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. +47 total
No map 0.593 0.438 No Hit 0.0% —
2370 VK055_2212 amino acid permease family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.593 0.614 Hit 26.3% 5.48e-16
2371 VK055_2656 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase hpaI AlphaFold DB model + ColabFold model
4.1.2.52
GO:0018802OBSOLETE. Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. +47 total
Chokepoint 1 0.592 0.564 No Hit 0.0% —
2372 VK055_0363 bacterial extracellular solute-binding, 3 familyprotein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
No map 0.592 0.859 Hit 34.0% 1.22e-08
2373 VK055_3626 putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD AlphaFold DB model + ColabFold model
3.5.1.n3
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +58 total
No map 0.591 0.709 No Hit 0.0% —
2374 VK055_2822 PRD domain protein AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +25 total
No map 0.591 0.376 No Hit 0.0% —
2375 VK055_2750 SIR2-like domain protein AlphaFold DB model + ColabFold model – – No map 0.591 0.664 No Hit 0.0% —
Page of 204 · 5081 total proteins