Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
226 KP13_00372 Maltose-binding periplasmic protein malE AlphaFold + ColabFold –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0015144Enables the transfer of carbohydrate from one side of a membrane to the other. +58 total
0.641 No Hit 0.0% —
227 KP13_00374 Maltoporin 2 lamB2 AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0042956The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane. GO:0034219The process in which a carbohydrate is transported across a membrane. +710 total
0.718 No Hit 0.0% —
228 KP13_00375 Maltose operon periplasmic protein malM AlphaFold + ColabFold –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.431 No Hit 0.0% —
229 KP13_00376 Chorismate--pyruvate lyase ubiC AlphaFold + ColabFold
4.1.3.40
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008813Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. +25 total
0.748 No Hit 0.0% —
230 KP13_00379 Diacylglycerol kinase dgkA AlphaFold + ColabFold
2.7.1.107
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004143Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +69 total
0.837 No Hit 0.0% —
231 KP13_00380 LexA repressor lexA AlphaFold + ColabFold
3.4.21.88
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009432An error-prone process for repairing damaged microbial DNA. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +58 total
0.237 No Hit 0.0% —
232 KP13_00381 DNA-damage-inducible protein F dinF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +25 total
0.788 No Hit 0.0% —
233 KP13_00382 General stress response CsbD-like protein AlphaFold + ColabFold – – 0.639 No Hit 0.0% —
234 KP13_00384 hypothetical protein AlphaFold + ColabFold – – 0.368 No Hit 0.0% —
235 KP13_00387 Phage shock protein G AlphaFold + ColabFold – – 0.5 No Hit 0.0% —
236 KP13_00389 Replicative DNA helicase dnaB AlphaFold + ColabFold
5.6.2.3
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +710 total
0.535 No Hit 0.0% —
237 KP13_00390 Alanine racemase, biosynthetic alr AlphaFold + ColabFold
5.1.1.1
GO:0006522OBSOLETE. The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
0.551 No Hit 0.0% —
238 KP13_00392 Class B acid phosphatase aphA AlphaFold + ColabFold –
GO:0003993Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.338 No Hit 0.0% —
239 KP13_00393 hypothetical protein AlphaFold + ColabFold – – 0.312 No Hit 0.0% —
240 KP13_00394 hypothetical protein AlphaFold + ColabFold – – 0.128 No Hit 0.0% —
241 KP13_00397 Lytic transglycosylase protein AlphaFold + ColabFold – – 0.66 No Hit 0.0% —
242 KP13_00398 hypothetical protein AlphaFold + ColabFold – – 0.415 No Hit 0.0% —
243 KP13_00399 Ferrienterobactin receptor fepA AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). +58 total
0.843 No Hit 0.0% —
244 KP13_00400 Transcriptional regulator, AraC family protein AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.745 No Hit 0.0% —
245 KP13_00402 hypothetical protein AlphaFold + ColabFold – – 0.613 No Hit 0.0% —
246 KP13_00403 Outer membrane protein assembly factor AlphaFold + ColabFold –
GO:0071709The aggregation, arrangement and bonding together of a set of components to form a membrane. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +25 total
0.771 No Hit 0.0% —
247 KP13_00404 hypothetical protein AlphaFold + ColabFold – – 0.307 No Hit 0.0% —
248 KP13_00405 Anti-adapter protein iraM iraM AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009267Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
0.169 No Hit 0.0% —
249 KP13_00408 Metallo-beta-lactamase superfamily protein AlphaFold + ColabFold –
GO:0042781Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.
0.445 No Hit 0.0% —
250 KP13_00410 putative spermidine/putrescine-binding periplasmic AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.72 No Hit 0.0% —
Page of 234 · 5842 total proteins