Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2576 KP13_01931 Sugar efflux transporter A setA AlphaFold DB model + ColabFold model –
GO:0005351Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +69 total
No map 0.442 No Hit 0.0% —
2577 KP13_01932 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.045 No Hit 0.0% —
2578 KP13_01933 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0046325Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell.
No map 0.416 No Hit 0.0% —
2579 KP13_01934 HTH-type transcriptional regulator sgrR sgrR AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.949 No Hit 0.0% —
2580 KP13_01935 Thiamine-binding periplasmic protein thiB AlphaFold DB model + ColabFold model –
GO:0030975Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0015888The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
No map 0.928 No Hit 0.0% —
2581 KP13_01939 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.833 No Hit 0.0% —
2582 KP13_01940 Arabinose operon regulatory protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.763 No Hit 0.0% —
2583 KP13_01941 hypothetical protein ColabFold model – – No map 0.32 No Hit 0.0% —
2584 KP13_01943 L-arabinose isomerase araA AlphaFold DB model + ColabFold model
5.3.1.4
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005996The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0008733Catalysis of the reaction: L-arabinose = L-ribulose. +47 total
No map 0.441 No Hit 0.0% —
2585 KP13_01944 L-ribulose-5-phosphate 4-epimerase araD AlphaFold DB model + ColabFold model
5.1.3.4
GO:0019572The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose. GO:0008270Binding to a zinc ion (Zn). GO:0019569The chemical reactions and pathways resulting in the breakdown of L-arabinose into D-xylulose 5-phosphate. +36 total
No map 0.405 No Hit 0.0% —
2586 KP13_01948 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.609 No Hit 0.0% —
2587 KP13_01949 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase citX AlphaFold DB model + ColabFold model
2.7.7.61
GO:0051191The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. GO:0050519Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase.
No map 0.394 No Hit 0.0% —
2588 KP13_01950 Citrate/malate transporter cimH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015711The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. GO:0008514OBSOLETE. Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. +36 total
No map 0.619 No Hit 0.0% —
2589 KP13_01951 Sensor histidine kinase CitA citA AlphaFold DB model + ColabFold model –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +14 total
No map 0.933 No Hit 0.0% —
2590 KP13_01952 Transcriptional regulatory protein CitB citB AlphaFold DB model + ColabFold model –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.705 No Hit 0.0% —
2591 KP13_01953 DnaJ-like protein djlA djlA AlphaFold DB model + ColabFold model –
GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.968 No Hit 0.0% —
2592 KP13_01954 LPS-assembly protein lptD lptD Experimental + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015920The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. +47 total
No map 0.656 No Hit 0.0% —
2593 KP13_01955 Chaperone surA surA AlphaFold DB model + ColabFold model
5.2.1.8
GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). +47 total
No map 0.5 No Hit 0.0% —
2594 KP13_01956 4-hydroxythreonine-4-phosphate dehydrogenase 1 pdxA1 AlphaFold DB model + ColabFold model –
GO:0042823The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0050570Catalysis of the reaction: 4-(phosphooxy)-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.
No map 0.145 No Hit 0.0% —
2595 KP13_01959 Bis(5'-nucleosyl)-tetraphosphatase, symmetrical apaH AlphaFold DB model + ColabFold model
3.6.1.41
GO:0008803Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.609 No Hit 0.0% —
2596 KP13_01963 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.271 No Hit 0.0% —
2597 KP13_01966 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.481 No Hit 0.0% —
2598 KP13_01967 Dihydrodipicolinate reductase dapB AlphaFold DB model + ColabFold model
1.17.1.8
GO:0008839Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
No map 0.729 No Hit 0.0% —
2599 KP13_01969 putative HTH-type transcriptional regulator ltrA ltrA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.273 No Hit 0.0% —
2600 KP13_01970 Non-specific ribonucleoside hydrolase rihC rihC AlphaFold DB model + ColabFold model
3.2.-.-
GO:0016798Catalysis of the hydrolysis of any glycosyl bond. GO:0016799Catalysis of the hydrolysis of any N-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
No map 0.244 No Hit 0.0% —
Page of 234 · 5842 total proteins