Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
251 KP13_01043 3-ketoacyl-CoA thiolase fadI AlphaFold + ColabFold
2.3.1.16
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
0.76 Hit 47.8% 7.17e-59
252 KP13_01072 2-hydroxy-3-oxopropionate reductase garR AlphaFold + ColabFold
1.1.1.60
GO:0008679Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
0.239 Hit 36.8% 1.11e-26
253 KP13_01074 putative galactarate transporter garP AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.91 Hit 27.8% 1.63e-19
254 KP13_01083 putative NADH dehydrogenase AlphaFold + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.152 Hit 30.0% 5.22e-25
255 KP13_01084 peptidase C56 protein AlphaFold + ColabFold – – 0.627 Hit 27.8% 2.99e-06
256 KP13_01093 Cold-shock DEAD box protein A deaD AlphaFold + ColabFold
3.6.4.13
GO:0070417Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. GO:0003676Binding to a nucleic acid. GO:0003724Unwinding of an RNA helix, driven by ATP hydrolysis. +912 total
0.46 Hit 50.8% 6.23e-12
257 KP13_01098 tRNA pseudouridine synthase B truB AlphaFold + ColabFold
5.4.99.25
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. +58 total
0.398 Hit 41.5% 3.73e-08
258 KP13_01100 Translation initiation factor IF-2 infB AlphaFold + ColabFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. +36 total
0.644 Hit 41.5% 5.97e-126
259 KP13_01103 Argininosuccinate synthase argG AlphaFold + ColabFold
6.3.4.5
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004055Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +47 total
0.554 Hit 29.6% 3.31e-18
260 KP13_01108 Phosphoglucosamine mutase glmM AlphaFold + ColabFold
5.4.2.10
GO:0008966Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0071704OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. +69 total
0.46 Hit 30.6% 1.45e-08
261 KP13_01110 Cell division protease ftsH ftsH AlphaFold + ColabFold
3.4.24.-
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0008270Binding to a zinc ion (Zn). GO:0004176Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. +69 total
0.765 Hit 58.8% 6.65e-46
262 KP13_01111 Ribosomal RNA large subunit methyltransferase E rlmE AlphaFold + ColabFold
2.1.1.166
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +47 total
0.115 Hit 40.5% 1.45e-15
263 KP13_01115 GTPase obg obg AlphaFold + ColabFold
3.6.5.-
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0000287Binding to a magnesium (Mg) ion. +47 total
0.603 Hit 44.2% 5.00e-17
264 KP13_01117 50S ribosomal protein L27 rpmA AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +36 total
0.519 Hit 41.9% 7.20e-08
265 KP13_01119 Octaprenyl-diphosphate synthase ispB AlphaFold + ColabFold –
GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
0.903 Hit 31.0% 8.67e-42
266 KP13_01122 BolA domain-containing protein AlphaFold + ColabFold – – 0.261 Hit 35.0% 2.86e-07
267 KP13_01130 Putative aldolase class 2 protein Experimental + ColabFold
4.1.1.104
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. GO:0046872Binding to a metal ion. +14 total
0.345 Hit 28.3% 3.74e-06
268 KP13_01131 putative epimerase/isomerase AlphaFold + ColabFold –
GO:0008903Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. GO:0046487The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
0.481 Hit 48.6% 1.47e-64
269 KP13_01143 hypothetical protein AlphaFold + ColabFold –
GO:0003697Binding to single-stranded DNA. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. GO:0018142OBSOLETE. The formation of a covalent cross-link between DNA and a protein.
0.096 Hit 33.3% 2.35e-07
270 KP13_01146 Peptidyl-dipeptidase dcp dcp AlphaFold + ColabFold
3.4.15.5
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. +58 total
0.336 Hit 34.7% 4.45e-24
271 KP13_01147 NADP-dependent L-serine/L-allo-threonine dehydrogenase AlphaFold + ColabFold
1.1.1.298 1.1.1.381
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0035527Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH.
0.472 Hit 40.0% 1.65e-08
272 KP13_01151 Inner membrane transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.914 Hit 24.9% 1.48e-09
273 KP13_01163 NAGC-like transcriptional regulator mlc AlphaFold + ColabFold – – 0.209 Hit 24.7% 2.59e-11
274 KP13_01165 Inner membrane transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.751 Hit 30.0% 3.32e-07
275 KP13_01177 Malonate decarboxylase subunit beta mdcD AlphaFold + ColabFold –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. +36 total
0.771 Hit 28.6% 1.06e-07
Page of 234 · 5842 total proteins