Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3001 KP13_01413 Plasmid stability protein B parB AlphaFold DB model + ColabFold model – – No map 0.488 No Hit 0.0% —
3002 KP13_01057 Lysozyme-related protein AlphaFold DB model + ColabFold model – – No map 0.488 No Hit 0.0% —
3003 KP13_00305 Glutathione reductase gor AlphaFold DB model + ColabFold model –
GO:0006749The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. GO:0016668Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +47 total
No map 0.488 Hit 54.3% 5.18e-161
3004 KP13_32242 Type II secretion system protein E AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.487 No Hit 0.0% —
3005 KP13_31632 Na(+)-translocating NADH-quinone reductase subunit A nqrA AlphaFold DB model + ColabFold model
7.2.1.1
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.487 No Hit 0.0% —
3006 KP13_07162 Ribosomal RNA small subunit methyltransferase G rsmG AlphaFold DB model + ColabFold model
2.1.1.170
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +25 total
No map 0.487 No Hit 0.0% —
3007 KP13_03817 DNA replication initiation factor hda AlphaFold DB model + ColabFold model –
GO:0032297Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.
No map 0.487 No Hit 0.0% —
3008 KP13_01760 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.487 No Hit 0.0% —
3009 KP13_00020 ATP synthase subunit c atpE AlphaFold DB model + ColabFold model –
GO:0015078Enables the transfer of a proton from one side of a membrane to the other. GO:1902600The directed movement of a proton across a membrane. GO:0015986The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). +69 total
No map 0.487 No Hit 0.0% —
3010 KP13_04527 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit fdnH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015944The chemical reactions and pathways by which formate is converted to CO2. GO:0045333The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). +69 total
No map 0.486 No Hit 0.0% —
3011 KP13_04295 Hexuronate transporter exuT AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
No map 0.486 Hit 27.8% 5.31e-11
3012 KP13_03383 Methylthioribose kinase mtnK AlphaFold DB model + ColabFold model
2.7.1.100
GO:0046522Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H+. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
No map 0.486 No Hit 0.0% —
3013 KP13_02686 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.486 No Hit 0.0% —
3014 KP13_01744 IMPACT family member AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043168Binding to an anion, a charged atom or group of atoms with a net negative charge. GO:0032561Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. +25 total
No map 0.486 No Hit 0.0% —
3015 KP13_00612 Protein fdhE fdhE AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008199Binding to a ferric iron ion, Fe(III). +14 total
No map 0.486 No Hit 0.0% —
3016 KP13_03297 Potassium-transporting ATPase C chain kdpC AlphaFold DB model + ColabFold model –
GO:0006813The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008556Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). +25 total
No map 0.485 No Hit 0.0% —
3017 KP13_02854 Putrescine aminotransferase patA AlphaFold DB model + ColabFold model
2.6.1.82 2.6.1.29
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0009447The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. +58 total
No map 0.485 Hit 33.3% 2.25e-61
3018 KP13_02732 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.485 No Hit 0.0% —
3019 KP13_00498 Microcin H47 secretion protein mchE mchE AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.485 No Hit 0.0% —
3020 KP13_00342 Cell division ATP-binding protein ftsE ftsE AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +25 total
No map 0.485 Hit 34.2% 7.25e-25
3021 KP13_04401 putative ABC transporter system periplasmic protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +36 total
No map 0.484 No Hit 0.0% —
3022 KP13_04276 Soluble aldose sugar dehydrogenase AlphaFold DB model + ColabFold model – – No map 0.484 Hit 28.5% 6.55e-14
3023 KP13_03229 Nucleotide-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003723Binding to an RNA molecule or a portion thereof.
No map 0.484 No Hit 0.0% —
3024 KP13_00677 4-alpha-glucanotransferase malQ AlphaFold DB model + ColabFold model
2.4.1.25
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004134Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.
No map 0.484 No Hit 0.0% —
3025 KP13_05100 putative endoribonuclease AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
No map 0.483 No Hit 0.0% —
Page of 208 · 5192 total proteins