Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3126 KP13_31622 Lipopolysaccharide export system protein lptA lptA Experimental + AlphaFold + ColabFold –
GO:0001530Binding to a lipopolysaccharide. GO:0015920The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.465 No Hit 0.0% —
3127 KP13_03924 hypothetical protein AlphaFold + ColabFold – – No map 0.465 No Hit 0.0% —
3128 KP13_03018 Imidazolonepropionase hutI AlphaFold + ColabFold
3.5.2.7
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. +69 total
No map 0.465 Hit 34.1% 1.44e-54
3129 KP13_05092 hypothetical protein AlphaFold + ColabFold –
GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
No map 0.464 No Hit 0.0% —
3130 KP13_04025 Phage major capsid protein, HK97 AlphaFold + ColabFold – – No map 0.464 No Hit 0.0% —
3131 KP13_02103 hypothetical protein AlphaFold + ColabFold –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.464 No Hit 0.0% —
3132 KP13_01547 Murein tetrapeptide carboxypeptidase ldcA AlphaFold + ColabFold
3.4.17.13
GO:0106415GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map 0.464 No Hit 0.0% —
3133 KP13_32240 putative HTH transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.463 No Hit 0.0% —
3134 KP13_04717 Nitrate reductase nasA AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0043546Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
No map 0.463 No Hit 0.0% —
3135 KP13_04146 Tellurium resistance protein terB terB AlphaFold + ColabFold – – No map 0.463 No Hit 0.0% —
3136 KP13_02079 Recombination-associated protein rdgC rdgC AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.463 No Hit 0.0% —
3137 KP13_01580 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005384Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.
No map 0.463 No Hit 0.0% —
3138 KP13_01452 hypothetical protein AlphaFold + ColabFold – – No map 0.463 No Hit 0.0% —
3139 KP13_00842 Inositol-1-monophosphatase suhB AlphaFold + ColabFold
3.1.3.25
GO:0046854The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +69 total
No map 0.463 Hit 44.1% 1.44e-13
3140 KP13_31785 hypothetical protein AlphaFold + ColabFold – – No map 0.461 No Hit 0.0% —
3141 KP13_31548 Formate hydrogenlyase transcriptional activator fhlA AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +47 total
No map 0.461 No Hit 0.0% —
3142 KP13_05437 Peptide transport system ATP-binding protein sapD sapD AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.461 Hit 33.3% 2.16e-06
3143 KP13_04222 ATP-dependent Clp protease ATP-binding subunit clpA clpA AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0043335The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. +47 total
No map 0.461 Hit 41.7% 6.27e-38
3144 KP13_03644 Arabinogalactan endo-1,4-beta-galactosidase ganB AlphaFold + ColabFold
3.2.1.89
GO:0015926Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. GO:0031218Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans. GO:0045490The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.
No map 0.461 No Hit 0.0% —
3145 KP13_02491 hypothetical protein AlphaFold + ColabFold – – No map 0.461 No Hit 0.0% —
3146 KP13_02109 Homocysteine S-methyltransferase mmuM AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +36 total
No map 0.461 Hit 26.1% 6.88e-13
3147 KP13_00738 Protein tusC tusC AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
No map 0.461 No Hit 0.0% —
3148 KP13_31506 Phosphoserine phosphatase serB AlphaFold + ColabFold
3.1.3.3
GO:0036424Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid. GO:0006564The chemical reactions and pathways resulting in the formation of L-serine. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.46 Hit 34.1% 4.58e-20
3149 KP13_06718 hypothetical protein AlphaFold + ColabFold – – No map 0.46 No Hit 0.0% —
3150 KP13_04349 hypothetical protein AlphaFold + ColabFold – – No map 0.46 No Hit 0.0% —
Page of 208 · 5192 total proteins