Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3151 KP13_02944 2,5-diketo-D-gluconic acid reductase B dkgB AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990002Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH. +14 total
No map 0.46 Hit 45.5% 3.11e-10
3152 KP13_02376 hypothetical protein AlphaFold + ColabFold –
GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
No map 0.46 No Hit 0.0% —
3153 KP13_01984 Inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015360Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in). +14 total
No map 0.46 No Hit 0.0% —
3154 KP13_01215 Ascorbate-specific phosphotransferase enzyme IIB component ulaB AlphaFold + ColabFold
2.7.1.194
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.46 No Hit 0.0% —
3155 KP13_01108 Phosphoglucosamine mutase glmM AlphaFold + ColabFold
5.4.2.10
GO:0008966Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0071704OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. +69 total
No map 0.46 Hit 30.6% 1.45e-08
3156 KP13_01097 30S ribosomal protein S15 rpsO AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
No map 0.46 No Hit 0.0% —
3157 KP13_01093 Cold-shock DEAD box protein A deaD AlphaFold + ColabFold
3.6.4.13
GO:0070417Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. GO:0003676Binding to a nucleic acid. GO:0003724Unwinding of an RNA helix, driven by ATP hydrolysis. +912 total
No map 0.46 Hit 50.8% 6.23e-12
3158 KP13_03654 hypothetical protein AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +36 total
No map 0.459 Hit 25.2% 2.62e-07
3159 KP13_03515 Fructokinase scrK AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008865Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. +14 total
No map 0.459 Hit 28.9% 9.43e-17
3160 KP13_01415 hypothetical protein AlphaFold + ColabFold – – No map 0.459 No Hit 0.0% —
3161 KP13_01168 hypothetical protein AlphaFold + ColabFold – – No map 0.459 No Hit 0.0% —
3162 KP13_00317 Nickel import ATP-binding protein NikE nikE AlphaFold + ColabFold
7.2.2.11
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0016151Binding to a nickel (Ni) cation. +36 total
No map 0.459 Hit 38.5% 3.03e-06
3163 KP13_00155 CDP-diacylglycerol pyrophosphatase cdh AlphaFold + ColabFold
3.6.1.26
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008715Catalysis of the reaction: CDP-diacylglycerol + H2O = a phosphatidate + CMP + 2 H+. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. +25 total
No map 0.459 No Hit 0.0% —
3164 KP13_04820 hypothetical protein AlphaFold + ColabFold – – No map 0.458 No Hit 0.0% —
3165 KP13_03962 hypothetical protein AlphaFold + ColabFold – – No map 0.458 No Hit 0.0% —
3166 KP13_02805 Glutamate-ammonia-ligase adenylyltransferase glnE AlphaFold + ColabFold –
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0008882Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].
No map 0.458 No Hit 0.0% —
3167 KP13_02489 hypothetical protein AlphaFold + ColabFold – – No map 0.458 No Hit 0.0% —
3168 KP13_01909 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase murF AlphaFold + ColabFold –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0047480Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP. GO:0016881Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. +25 total
No map 0.458 No Hit 0.0% —
3169 KP13_01539 Proteasome subunit alpha/beta domain-containing protein AlphaFold + ColabFold –
GO:0005839A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
No map 0.458 No Hit 0.0% —
3170 KP13_00861 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase ispG AlphaFold + ColabFold –
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0005506Binding to an iron (Fe) ion. +25 total
No map 0.458 No Hit 0.0% —
3171 KP13_04581 hypothetical protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.457 No Hit 0.0% —
3172 KP13_03509 putative periplasmic binding protein AlphaFold + ColabFold – – No map 0.457 No Hit 0.0% —
3173 KP13_02477 Sigma-54 dependent transcriptional regulator AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +47 total
No map 0.457 No Hit 0.0% —
3174 KP13_01421 Transcriptional repressor protein korC korC AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.457 No Hit 0.0% —
3175 KP13_00860 Cytoskeleton protein rodZ rodZ AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008360Any process that modulates the surface configuration of a cell. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.457 No Hit 0.0% —
Page of 208 · 5192 total proteins