Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3351 KP13_02578 Formate hydrogenlyase subunit 7 hycG AlphaFold + ColabFold –
GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +25 total
No map 0.429 Hit 37.1% 9.65e-28
3352 KP13_15212 Phosphoenolpyruvate-protein phosphotransferase ptsP ptsP AlphaFold + ColabFold
2.7.3.9
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +69 total
No map 0.428 No Hit 0.0% —
3353 KP13_03258 hypothetical protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.428 No Hit 0.0% —
3354 KP13_01978 Transcriptional activator protein nhaR nhaR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.428 No Hit 0.0% —
3355 KP13_01654 Dihydrodipicolinate synthase dapA AlphaFold + ColabFold
4.3.3.7
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+.
No map 0.428 No Hit 0.0% —
3356 KP13_01488 Sulphatase-modifying factor domain-containing protein AlphaFold + ColabFold –
GO:0120147Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O.
No map 0.428 Hit 35.3% 1.71e-06
3357 KP13_00532 Protein hflK hflK AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map 0.427 Hit 25.0% 6.71e-06
3358 KP13_00528 DNA mismatch repair protein mutL mutL AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0030983Binding to a double-stranded DNA region containing one or more mismatches. +47 total
No map 0.427 Hit 47.5% 2.26e-12
3359 KP13_00254 Glyoxylate/hydroxypyruvate reductase B ghrB AlphaFold + ColabFold
1.1.1.79 1.1.1.81
GO:0016618Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0030267Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. +58 total
No map 0.427 Hit 40.2% 3.45e-58
3360 KP13_03418 Transketolase domain-containing protein AlphaFold + ColabFold
2.2.1.1
GO:0004802Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.
No map 0.426 Hit 39.4% 4.17e-15
3361 KP13_01569 hypothetical protein AlphaFold + ColabFold – – No map 0.426 No Hit 0.0% —
3362 KP13_05557 Phosphoglycerate transporter protein pgtP AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +47 total
No map 0.425 Hit 33.0% 1.73e-22
3363 KP13_05170 Endonuclease III nth AlphaFold + ColabFold
4.2.99.18
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003906Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. +710 total
No map 0.425 Hit 35.5% 4.82e-16
3364 KP13_05054 GTP cyclohydrolase 1 folE AlphaFold + ColabFold
3.5.4.16
GO:0003934Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+. GO:0046654The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.425 Hit 36.0% 2.62e-34
3365 KP13_04848 hypothetical protein AlphaFold + ColabFold – – No map 0.425 No Hit 0.0% —
3366 KP13_03813 Beta-glucoside kinase bglK AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
No map 0.425 Hit 26.3% 6.39e-16
3367 KP13_01981 Chaperone protein dnaK dnaK AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0051082Binding to an unfolded protein. GO:0140662Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. +25 total
No map 0.425 Hit 65.9% 4.46e-54
3368 KP13_00959 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB AlphaFold + ColabFold
1.17.4.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009263The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0046872Binding to a metal ion. +14 total
No map 0.425 Hit 24.2% 5.75e-11
3369 KP13_00647 sn-glycerol-3-phosphate-binding periplasmic protein ugpB ugpB AlphaFold + ColabFold –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.425 No Hit 0.0% —
3370 KP13_00208 2,3-bisphosphoglycerate-independent phosphoglycerate mutase gpmI AlphaFold + ColabFold
5.4.2.12
GO:0004619Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate. GO:0030145Binding to a manganese ion (Mn). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
No map 0.425 No Hit 0.0% —
3371 KP13_05344 hypothetical protein AlphaFold + ColabFold – – No map 0.424 No Hit 0.0% —
3372 KP13_01657 Response regulator uvrY uvrY AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.424 No Hit 0.0% —
3373 KP13_01431 Alpha-D-phosphohexomutase N-terminal domain-containing protein AlphaFold + ColabFold
5.4.2.10
GO:0016868Catalysis of the transfer of a phosphate group from one position to another within a single molecule. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
No map 0.424 No Hit 0.0% —
3374 KP13_01292 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
No map 0.424 No Hit 0.0% —
3375 KP13_06780 Regulatory protein rop rop AlphaFold + ColabFold – – No map 0.423 No Hit 0.0% —
Page of 208 · 5192 total proteins