Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3676 KP13_03605 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.407 No Hit 0.0% —
3677 KP13_03606 HTH-type transcriptional regulator CueR cueR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
No map 0.362 No Hit 0.0% —
3678 KP13_03608 pheromone shutdown protein TraB AlphaFold DB model + ColabFold model – – No map 0.944 No Hit 0.0% —
3679 KP13_03609 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase AlphaFold DB model + ColabFold model
4.2.-.-
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. +14 total
No map 0.843 No Hit 0.0% —
3680 KP13_03611 hypothetical protein ColabFold model – – No map 0.451 No Hit 0.0% —
3681 KP13_03612 Fosmidomycin resistance protein fsr AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.619 No Hit 0.0% —
3682 KP13_03613 hypothetical protein ColabFold model – – No map 0.431 No Hit 0.0% —
3683 KP13_03615 Inosine-guanosine kinase gsk AlphaFold DB model + ColabFold model
2.7.1.73
GO:0008906Catalysis of the reaction: ATP + inosine = ADP + IMP. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006166Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. +47 total
No map 0.71 No Hit 0.0% —
3684 KP13_03619 Recombination protein recR recR AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0046872Binding to a metal ion. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
No map 0.969 No Hit 0.0% —
3685 KP13_03620 nucleoid-associated protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.328 No Hit 0.0% —
3686 KP13_03623 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.938 No Hit 0.0% —
3687 KP13_03624 Primosomal replication protein N'' priC AlphaFold DB model + ColabFold model – – No map 0.79 No Hit 0.0% —
3688 KP13_03625 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.348 No Hit 0.0% —
3689 KP13_03626 hypothetical protein AlphaFold DB model + ColabFold model –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.589 No Hit 0.0% —
3690 KP13_03627 Potassium efflux system KefA kefA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.891 No Hit 0.0% —
3691 KP13_03628 HTH-type transcriptional regulator AcrR acrR AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +25 total
No map 0.869 No Hit 0.0% —
3692 KP13_03629 Acriflavine resistance protein A acrA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +47 total
No map 0.448 No Hit 0.0% —
3693 KP13_03630 Acriflavine resistance protein B acrB Experimental + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0042908The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +58 total
No map 0.997 No Hit 0.0% —
3694 KP13_03631 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.37 No Hit 0.0% —
3695 KP13_03632 Biofilm formation regulator YbaJ-like protein AlphaFold DB model + ColabFold model – – No map 0.442 No Hit 0.0% —
3696 KP13_03634 Maltose O-acetyltransferase maa AlphaFold DB model + ColabFold model –
GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.123 No Hit 0.0% —
3697 KP13_03635 Inner membrane protein AlphaFold DB model + ColabFold model – – No map 0.97 No Hit 0.0% —
3698 KP13_03637 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:1990189Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein]. GO:0008999Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-alanyl-[protein].
No map 0.919 No Hit 0.0% —
3699 KP13_03638 50S ribosomal protein L31 type B rpmE2 AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
No map 0.734 No Hit 0.0% —
3700 KP13_03644 Arabinogalactan endo-1,4-beta-galactosidase ganB AlphaFold DB model + ColabFold model
3.2.1.89
GO:0015926Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. GO:0031218Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans. GO:0045490The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.
No map 0.461 No Hit 0.0% —
Page of 234 · 5842 total proteins