Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3701 KP13_04641 ABC-type transport system, permease component AlphaFold + ColabFold – – 0.434 No Hit 0.0% —
3702 KP13_03826 Phosphoribosylaminoimidazole-succinocarboxamide synthase purC AlphaFold + ColabFold –
GO:0004639Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate. GO:0006164The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
0.434 Hit 31.7% 8.26e-28
3703 KP13_03506 hypothetical protein ColabFold – – 0.434 No Hit 0.0% —
3704 KP13_01779 Methionine import ATP-binding protein metN 1 metN1 AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0033232Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out). GO:0048473The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.434 Hit 67.6% 1.01e-07
3705 KP13_01279 Helix-turn-helix protein RpiR AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.434 No Hit 0.0% —
3706 KP13_31626 Ribosomal large subunit pseudouridine synthase D rluD AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. +14 total
0.433 Hit 43.4% 3.94e-06
3707 KP13_07065 hypothetical protein ColabFold – – 0.433 No Hit 0.0% —
3708 KP13_05559 hypothetical protein ColabFold – – 0.433 No Hit 0.0% —
3709 KP13_04742 Protein umuC umuC AlphaFold + ColabFold –
GO:0003684Binding to damaged DNA. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.433 Hit 27.2% 3.92e-08
3710 KP13_04261 Inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.433 No Hit 0.0% —
3711 KP13_03890 hypothetical protein AlphaFold + ColabFold – – 0.433 No Hit 0.0% —
3712 KP13_03554 Cysteine synthase A cysK AlphaFold + ColabFold
2.5.1.47
GO:0006535OBSOLETE. The chemical reactions and pathways resulting in the formation of cysteine from L- serine. GO:0004124Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.
0.433 Hit 52.4% 9.21e-24
3713 KP13_02679 hypothetical protein AlphaFold + ColabFold – – 0.433 No Hit 0.0% —
3714 KP13_02123 Amino acid ABC superfamily ATP binding cassette transporter, ABC protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.433 Hit 61.1% 6.83e-07
3715 KP13_01689 Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase wecA AlphaFold + ColabFold
2.7.8.33
GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0016780Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). GO:0030145Binding to a manganese ion (Mn). +1013 total
0.433 No Hit 0.0% —
3716 KP13_00544 Esterase Experimental + ColabFold
3.1.1.23
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0047372Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+.
0.433 No Hit 0.0% —
3717 KP13_04805 Type IV secretion system protein virB9 virB9 AlphaFold + ColabFold – – 0.432 No Hit 0.0% —
3718 KP13_02869 Inner membrane protein alx alx AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.432 No Hit 0.0% —
3719 KP13_02374 Protein syd syd AlphaFold + ColabFold –
GO:0009898The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.
0.432 No Hit 0.0% —
3720 KP13_00797 GNAT family acetyltransferase AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.432 No Hit 0.0% —
3721 KP13_00235 Xylose operon regulatory protein xylR AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.432 No Hit 0.0% —
3722 KP13_04181 Aspartate aminotransferase aspC AlphaFold + ColabFold
2.6.1.-
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. +710 total
0.431 Hit 42.7% 6.22e-101
3723 KP13_03613 hypothetical protein ColabFold – – 0.431 No Hit 0.0% —
3724 KP13_03370 ABC transporter permease family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.431 No Hit 0.0% —
3725 KP13_02430 putative inorganic polyphosphate/ATP-NAD kinase ppnK AlphaFold + ColabFold
2.7.1.23
GO:0003951Catalysis of the reaction: ATP + NAD+ = ADP + H+ + NADP+. GO:0006741The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions. GO:0019674The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. +47 total
0.431 Hit 27.6% 8.65e-19
Page of 234 · 5842 total proteins