Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3651 KP13_00505 Two-component response regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.441 No Hit 0.0% —
3652 KP13_04983 putative O-methyltransferase Experimental + ColabFold –
GO:0008171Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.
0.44 Hit 36.5% 6.21e-11
3653 KP13_04021 Putative terminase large subunit AlphaFold + ColabFold –
GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
0.44 No Hit 0.0% —
3654 KP13_03831 Succinyl-diaminopimelate desuccinylase dapE AlphaFold + ColabFold
3.5.1.18
GO:0009014Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + succinate. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +58 total
0.44 Hit 42.9% 2.76e-07
3655 KP13_00819 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.44 No Hit 0.0% —
3656 KP13_05160 Outer membrane lipoprotein slyB slyB AlphaFold + ColabFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
0.439 No Hit 0.0% —
3657 KP13_04506 putative ABC transporter substrate binding protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0046872Binding to a metal ion. GO:0030975Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. +25 total
0.439 No Hit 0.0% —
3658 KP13_03977 hypothetical protein AlphaFold + ColabFold – – 0.439 No Hit 0.0% —
3659 KP13_02846 hypothetical protein ColabFold – – 0.439 No Hit 0.0% —
3660 KP13_01028 Erythronate-4-phosphate dehydrogenase pdxB AlphaFold + ColabFold
1.1.1.290
GO:0008615The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0033711Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH. +58 total
0.439 Hit 31.2% 1.40e-11
3661 KP13_00755 30S ribosomal protein S3 rpsC AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0003676Binding to a nucleic acid. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +47 total
0.439 Hit 28.7% 1.94e-06
3662 KP13_32116 insertion element IS1 protein insA AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
3663 KP13_31948 exodeoxyribonuclease III xthA AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. +36 total
0.438 Hit 33.3% 3.39e-08
3664 KP13_31763 Insertion element IS1 protein insA AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
3665 KP13_07020 insertion element IS1 protein insA AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
3666 KP13_06784 insertion element IS1 protein insA AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
3667 KP13_05940 insertion element IS1 protein insA AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
3668 KP13_05565 insertion element IS1 protein insA AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
3669 KP13_05176 insertion element IS1 protein insA AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
3670 KP13_05067 insertion element IS1 protein insA AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
3671 KP13_05052 insertion element IS1 protein insA AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
3672 KP13_04974 putative 3-hydroxybutyryl-CoA dehydrogenase paaH AlphaFold + ColabFold –
GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +14 total
0.438 Hit 42.7% 2.11e-35
3673 KP13_03472 insertion element IS1 protein insA insA2 AlphaFold + ColabFold –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.438 No Hit 0.0% —
3674 KP13_03022 Histidine ammonia-lyase hutH AlphaFold + ColabFold
4.3.1.3
GO:0016841Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004397Catalysis of the reaction: L-histidine = trans-urocanate + NH4+. +47 total
0.438 Hit 50.3% 2.87e-36
3675 KP13_02799 dioxygenase class III protein, subunit B AlphaFold + ColabFold
1.13.11.29
GO:0008270Binding to a zinc ion (Zn). GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. GO:0016701Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. +47 total
0.438 No Hit 0.0% —
Page of 234 · 5842 total proteins