Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3726 KP13_01857 Pantothenate synthetase panC AlphaFold + ColabFold
6.3.2.1
GO:0015940The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. GO:0004592Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.431 No Hit 0.0% —
3727 KP13_01646 hypothetical protein AlphaFold + ColabFold – – 0.431 No Hit 0.0% —
3728 KP13_00790 hypothetical protein ColabFold – – 0.431 No Hit 0.0% —
3729 KP13_00375 Maltose operon periplasmic protein malM AlphaFold + ColabFold –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.431 No Hit 0.0% —
3730 KP13_04947 Glucans biosynthesis protein G mdoG AlphaFold + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +47 total
0.43 No Hit 0.0% —
3731 KP13_04569 hypothetical protein AlphaFold + ColabFold – – 0.43 No Hit 0.0% —
3732 KP13_03463 hypothetical protein AlphaFold + ColabFold – – 0.43 No Hit 0.0% —
3733 KP13_02219 Multidrug resistance protein mdtN mdtN AlphaFold + ColabFold – – 0.43 No Hit 0.0% —
3734 KP13_01204 Spermidine/putrescine ABC transporter permease component I ColabFold – – 0.43 No Hit 0.0% —
3735 KP13_00969 CinA-like protein AlphaFold + ColabFold – – 0.43 Hit 28.1% 7.07e-09
3736 KP13_05485 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.429 No Hit 0.0% —
3737 KP13_04353 hypothetical protein AlphaFold + ColabFold – – 0.429 No Hit 0.0% —
3738 KP13_02578 Formate hydrogenlyase subunit 7 hycG AlphaFold + ColabFold –
GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +25 total
0.429 Hit 37.1% 9.65e-28
3739 KP13_31784 hypothetical protein ColabFold – – 0.428 No Hit 0.0% —
3740 KP13_15212 Phosphoenolpyruvate-protein phosphotransferase ptsP ptsP AlphaFold + ColabFold
2.7.3.9
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +69 total
0.428 No Hit 0.0% —
3741 KP13_03258 hypothetical protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.428 No Hit 0.0% —
3742 KP13_01978 Transcriptional activator protein nhaR nhaR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.428 No Hit 0.0% —
3743 KP13_01654 Dihydrodipicolinate synthase dapA AlphaFold + ColabFold
4.3.3.7
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+.
0.428 No Hit 0.0% —
3744 KP13_01488 Sulphatase-modifying factor domain-containing protein AlphaFold + ColabFold –
GO:0120147Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O.
0.428 Hit 35.3% 1.71e-06
3745 KP13_00532 Protein hflK hflK AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.427 Hit 25.0% 6.71e-06
3746 KP13_00528 DNA mismatch repair protein mutL mutL AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0030983Binding to a double-stranded DNA region containing one or more mismatches. +47 total
0.427 Hit 47.5% 2.26e-12
3747 KP13_00254 Glyoxylate/hydroxypyruvate reductase B ghrB AlphaFold + ColabFold
1.1.1.79 1.1.1.81
GO:0016618Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0030267Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. +58 total
0.427 Hit 40.2% 3.45e-58
3748 KP13_06769 hypothetical protein ColabFold – – 0.426 No Hit 0.0% —
3749 KP13_03418 Transketolase domain-containing protein AlphaFold + ColabFold
2.2.1.1
GO:0004802Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.
0.426 Hit 39.4% 4.17e-15
3750 KP13_01569 hypothetical protein AlphaFold + ColabFold – – 0.426 No Hit 0.0% —
Page of 234 · 5842 total proteins