Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
351 KP13_04992 Arginine N-succinyltransferase AlphaFold DB model + ColabFold model
2.3.1.109
GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0008791Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+.
No map 0.963 0.265 No Hit 0.0% —
352 KP13_04325 putative glucarate transporter AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.963 0.993 Hit 25.3% 7.83e-17
353 KP13_03203 Porin B oprB AlphaFold DB model + ColabFold model –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
No map 0.963 0.723 No Hit 0.0% —
354 KP13_01295 Fructosamine kinase frlD frlD AlphaFold DB model + ColabFold model – – No map 0.963 0.614 No Hit 0.0% —
355 KP13_31942 Farnesyl diphosphate synthase ispA AlphaFold DB model + ColabFold model –
GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. +36 total
No map 0.962 0.652 Hit 29.0% 2.50e-12
356 KP13_04812 Type IV secretion system protein ptlA ptlA AlphaFold DB model + ColabFold model – – No map N/A 0.962 No Hit 0.0% —
357 KP13_04751 Adenosylhomocysteinase ahcY AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004013Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. GO:0006730The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. +14 total
No map 0.962 0.648 Hit 33.0% 6.62e-40
358 KP13_04619 D-galactonate transporter AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.962 0.409 Hit 33.0% 3.03e-06
359 KP13_04542 Alcohol dehydrogenase, propanol-preferring adhP AlphaFold DB model + ColabFold model
1.1.1.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn). GO:0004022Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
No map 0.962 0.784 Hit 44.6% 4.93e-07
360 KP13_02845 Glycerol dehydrogenase dhaD AlphaFold DB model + ColabFold model
1.1.1.6
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0046872Binding to a metal ion. +47 total
No map 0.962 0.61 No Hit 0.0% —
361 KP13_02138 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.962 0.964 No Hit 0.0% —
362 KP13_02105 Alpha-ketoglutarate-dependent taurine dioxygenase tauD AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. +25 total
No map 0.962 0.694 No Hit 0.0% —
363 KP13_00004 Ribokinase rbsK AlphaFold DB model + ColabFold model –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006014The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. GO:0004747Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate.
No map 0.962 0.713 Hit 44.9% 3.14e-06
364 KP13_31808 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase AlphaFold DB model + ColabFold model
2.1.1.14
GO:0008270Binding to a zinc ion (Zn). GO:0003871Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +36 total
No map 0.961 0.894 No Hit 0.0% —
365 KP13_31572 Aminoglycoside N(6')-acetyltransferase aacA4 AlphaFold DB model + ColabFold model
2.3.1.82
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0047663Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H+. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
No map 0.961 0.042 No Hit 0.0% —
366 KP13_31559 Inner membrane protein AlphaFold DB model + ColabFold model
2.3.1.-
GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016413Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. +14 total
No map 0.961 0.688 No Hit 0.0% —
367 KP13_05188 putative pentose kinase AlphaFold DB model + ColabFold model –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
No map 0.961 0.153 Hit 23.6% 1.46e-20
368 KP13_04827 AraC-type transcriptional regulator for yersiniabactin uptake AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.961 0.92 No Hit 0.0% —
369 KP13_04713 Nitrite extrusion protein 1 narK AlphaFold DB model + ColabFold model –
GO:0015707The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015112Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +710 total
No map 0.961 0.818 No Hit 0.0% —
370 KP13_04699 Aldehyde-alcohol dehydrogenase adhE AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion. GO:0008774Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +47 total
No map 0.961 0.741 Hit 27.4% 1.87e-08
371 KP13_03778 putative glycosyltransferase family 2 AlphaFold DB model + ColabFold model
2.4.1.212
GO:0050501Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP.
No map 0.961 0.783 Hit 38.3% 7.60e-06
372 KP13_02781 elongator protein 3/MiaB/NifB domain-containing protein AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
No map 0.961 0.546 No Hit 0.0% —
373 KP13_02509 YfaZ family protein AlphaFold DB model + ColabFold model – – No map 0.961 0.901 No Hit 0.0% —
374 KP13_02392 7-carboxy-7-deazaguanine synthase-like protein AlphaFold DB model + ColabFold model
4.3.99.3
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +47 total
No map 0.961 0.201 No Hit 0.0% —
375 KP13_02344 moeB family protein AlphaFold DB model + ColabFold model –
GO:0008641Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +25 total
No map 0.961 0.751 Hit 33.3% 1.93e-08
Page of 234 · 5842 total proteins