Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5192 / 5842 proteins Structure: AlphaFold

Scoring formula None

Sorted by Druggability (descending)

Applied filters Structure: AlphaFold

Search query No active search

Rows per page 25

Rows
Active criteria 1
Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3726 KP13_04623 hypothetical protein AlphaFold + ColabFold – – 0.366 No Hit 0.0% —
3727 KP13_03095 hypothetical protein AlphaFold + ColabFold – – 0.366 No Hit 0.0% —
3728 KP13_02078 Fructokinase mak AlphaFold + ColabFold –
GO:0004396Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
0.366 Hit 25.3% 2.56e-10
3729 KP13_00741 30S ribosomal protein S7 rpsG AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0015935The smaller of the two subunits of a ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.366 Hit 32.9% 4.79e-25
3730 KP13_00008 D-ribose pyranase rbsD AlphaFold + ColabFold
5.4.99.62
GO:0005996The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0048029Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. +47 total
0.366 No Hit 0.0% —
3731 KP13_12802 L-serine dehydratase 1 sdaA AlphaFold + ColabFold
4.3.1.17
GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003941Catalysis of the reaction: L-serine = pyruvate + NH4+. +25 total
0.365 No Hit 0.0% —
3732 KP13_05267 hypothetical protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.365 No Hit 0.0% —
3733 KP13_05133 decarboxylase family protein AlphaFold + ColabFold
3.2.2.n1
GO:0009691The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.365 No Hit 0.0% —
3734 KP13_03830 hypothetical protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.365 No Hit 0.0% —
3735 KP13_02222 acyltransferase domain-containing protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.365 No Hit 0.0% —
3736 KP13_00356 Peptidase E pepE AlphaFold + ColabFold
3.4.13.21
GO:0016805Catalysis of the hydrolysis of a dipeptide. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +14 total
0.365 No Hit 0.0% —
3737 KP13_11777 hypothetical protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009306The controlled release of proteins from a cell. GO:0097347A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane.
0.364 No Hit 0.0% —
3738 KP13_09908 3-dehydroquinate synthase aroB AlphaFold + ColabFold
4.2.3.4
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). GO:0016838Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate. +58 total
0.364 No Hit 0.0% —
3739 KP13_04969 Phenylacetic acid degradation protein paaC paaC Experimental + AlphaFold + ColabFold –
GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate.
0.364 No Hit 0.0% —
3740 KP13_04923 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042254A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
0.364 No Hit 0.0% —
3741 KP13_03866 putative lipoprotein AlphaFold + ColabFold – – 0.364 No Hit 0.0% —
3742 KP13_00931 hypothetical protein AlphaFold + ColabFold – – 0.364 No Hit 0.0% —
3743 KP13_31583 putative ABC transporter AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.363 Hit 34.6% 1.01e-12
3744 KP13_02261 Putative ABC transporter substrate-binding protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.363 No Hit 0.0% —
3745 KP13_02087 Pyrroline-5-carboxylate reductase proC AlphaFold + ColabFold
1.5.1.2
GO:0006561OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. GO:0004735Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.363 Hit 50.6% 1.03e-19
3746 KP13_01519 ABC transporter, periplasmic substrate-binding protein AlphaFold + ColabFold –
GO:0030973Binding to a molybdate ion (MoO4 2-). GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
0.363 No Hit 0.0% —
3747 KP13_00688 Transcriptional regulatory protein ompR ompR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
0.363 No Hit 0.0% —
3748 KP13_06679 hypothetical protein AlphaFold + ColabFold – – 0.362 No Hit 0.0% —
3749 KP13_05041 3-oxoadipate CoA-transferase subunit B pcaJ AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.362 Hit 44.7% 1.22e-53
3750 KP13_03606 HTH-type transcriptional regulator CueR cueR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.362 No Hit 0.0% —
Page of 208 · 5192 total proteins