Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3726 KP13_03698 Inner membrane transport protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.991 No Hit 0.0% —
3727 KP13_03699 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.125 No Hit 0.0% —
3728 KP13_03700 2-dehydropantoate 2-reductase panE AlphaFold DB model + ColabFold model
1.1.1.169
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008677Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH. GO:0015940The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. +25 total
No map 0.241 No Hit 0.0% —
3729 KP13_03702 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.631 No Hit 0.0% —
3730 KP13_03703 tRNA sulfurtransferase thiI AlphaFold DB model + ColabFold model
2.8.1.4
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0052837The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position. GO:0004810Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate. +912 total
No map 0.958 No Hit 0.0% —
3731 KP13_03704 Exodeoxyribonuclease 7 small subunit xseB AlphaFold DB model + ColabFold model
3.1.11.6
GO:0008855Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. GO:0006308The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. GO:0009318An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA. +14 total
No map 0.394 No Hit 0.0% —
3732 KP13_03707 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0046872Binding to a metal ion.
No map 0.158 No Hit 0.0% —
3733 KP13_03708 GCN5-related N-acetyltransferase Experimental + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.932 No Hit 0.0% —
3734 KP13_03709 hypothetical protein Experimental + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.73 No Hit 0.0% —
3735 KP13_03710 Sensor kinase cusS cusS AlphaFold DB model + ColabFold model
2.7.13.3
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0004673Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. +69 total
No map 0.869 No Hit 0.0% —
3736 KP13_03711 Transcriptional regulatory protein cusR cusR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
No map 0.314 No Hit 0.0% —
3737 KP13_03712 Cation efflux system protein cusC cusC AlphaFold DB model + ColabFold model –
GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.713 No Hit 0.0% —
3738 KP13_03713 Cation efflux system protein cusF cusF AlphaFold DB model + ColabFold model – – No map 0.221 No Hit 0.0% —
3739 KP13_03714 Cation efflux system protein cusB cusB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0046872Binding to a metal ion. +58 total
No map 0.318 No Hit 0.0% —
3740 KP13_03715 Cation efflux system protein cusA cusA AlphaFold DB model + ColabFold model –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0008324Enables the transfer of cation from one side of a membrane to the other. +58 total
No map 0.942 No Hit 0.0% —
3741 KP13_03716 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.575 No Hit 0.0% —
3742 KP13_03718 HTH-type transcriptional regulator mlrA mlrA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.043 No Hit 0.0% —
3743 KP13_03719 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.859 No Hit 0.0% —
3744 KP13_03721 putative flavin-containing monoamine oxidase AofH AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.929 No Hit 0.0% —
3745 KP13_03722 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.989 No Hit 0.0% —
3746 KP13_03723 Cyclopropane-fatty-acyl-phospholipid synthase cfa AlphaFold DB model + ColabFold model –
GO:0008610The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
No map 0.998 No Hit 0.0% —
3747 KP13_03724 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.998 No Hit 0.0% —
3748 KP13_03725 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.665 No Hit 0.0% —
3749 KP13_03726 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.828 No Hit 0.0% —
3750 KP13_03727 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.759 No Hit 0.0% —
Page of 234 · 5842 total proteins