Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3776 KP13_03766 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.351 No Hit 0.0% —
3777 KP13_03767 ATP phosphoribosyltransferase hisG AlphaFold DB model + ColabFold model
2.4.2.17
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0003879Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. +25 total
No map 0.29 No Hit 0.0% —
3778 KP13_03768 Histidinol dehydrogenase hisD AlphaFold DB model + ColabFold model
1.1.1.23
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0046872Binding to a metal ion. +58 total
No map 0.866 No Hit 0.0% —
3779 KP13_03770 Histidine biosynthesis bifunctional protein hisB AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0004424Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. +36 total
No map 0.318 No Hit 0.0% —
3780 KP13_03771 Imidazole glycerol phosphate synthase subunit hisH hisH AlphaFold DB model + ColabFold model
4.3.2.10 3.5.1.2
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
No map 0.516 No Hit 0.0% —
3781 KP13_03772 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA AlphaFold DB model + ColabFold model
5.3.1.16
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0003949Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.968 No Hit 0.0% —
3782 KP13_03773 Imidazole glycerol phosphate synthase subunit hisF AlphaFold DB model + ColabFold model
4.3.2.10
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.997 No Hit 0.0% —
3783 KP13_03774 Histidine biosynthesis bifunctional protein hisIE hisI AlphaFold DB model + ColabFold model –
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0004635Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide. GO:0004636Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+. +25 total
No map 0.367 No Hit 0.0% —
3784 KP13_03776 putative glycosyltransferase family 2 AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
No map 0.522 No Hit 0.0% —
3785 KP13_03779 putative glycosyltransferase group 1 AlphaFold DB model + ColabFold model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
No map 0.997 No Hit 0.0% —
3786 KP13_03780 putative glycosyltransferase family 2 AlphaFold DB model + ColabFold model – – No map 0.543 No Hit 0.0% —
3787 KP13_03781 putative UDP-galactopyranose mutase rfbD Experimental + ColabFold model
5.4.99.9
GO:0008767Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +14 total
No map 0.902 No Hit 0.0% —
3788 KP13_03784 Lipopolysaccharide O-antigen ABC transport system transmembrane component rfbA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.846 No Hit 0.0% —
3789 KP13_03785 hypothetical protein ColabFold model – – No map 0.382 No Hit 0.0% —
3790 KP13_03787 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.662 No Hit 0.0% —
3791 KP13_03788 Pectin lyase-like superfamily protein AlphaFold DB model + ColabFold model – – No map 0.904 No Hit 0.0% —
3792 KP13_03789 Wzy polymerase in cps region wzy AlphaFold DB model + ColabFold model – – No map 0.82 No Hit 0.0% —
3793 KP13_03790 putative transposase ColabFold model – – No map 0.303 No Hit 0.0% —
3794 KP13_03791 putative glycosyltransferase family 2 AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.697 No Hit 0.0% —
3795 KP13_03795 dTDP-4-dehydrorhamnose 3,5-epimerase in cps region rmlC AlphaFold DB model + ColabFold model
5.1.3.13
GO:0008830Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019305The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate. +14 total
No map 0.188 No Hit 0.0% —
3796 KP13_03802 putative glycosyltransferase in cps region AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.165 No Hit 0.0% —
3797 KP13_03803 putative glycosyltransferase family 2 in cps region AlphaFold DB model + ColabFold model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
No map 0.012 No Hit 0.0% —
3798 KP13_03804 putative glycosyltransferase family 2 in cps region rfbN AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
No map 0.265 No Hit 0.0% —
3799 KP13_03806 putative tyrosine-protein kinase in cps region wzc AlphaFold DB model + ColabFold model
2.7.10.2 2.7.10.-
GO:0045226OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. +58 total
No map 0.642 No Hit 0.0% —
3800 KP13_03808 Capsule polysaccharide export protein in cps region wza AlphaFold DB model + ColabFold model –
GO:0015774The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0015159Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
No map 0.452 No Hit 0.0% —
Page of 234 · 5842 total proteins