Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3801 KP13_03696 4-hydroxybenzoate transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.417 Hit 33.3% 5.89e-09
3802 KP13_03100 hypothetical protein AlphaFold + ColabFold – – 0.417 No Hit 0.0% —
3803 KP13_02206 Glutathione-regulated potassium-efflux system ancillary protein AlphaFold + ColabFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol.
0.417 Hit 39.5% 3.27e-08
3804 KP13_01896 8-oxo-dGTP diphosphatase mutT Experimental + ColabFold
3.6.1.55
GO:0008413Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +58 total
0.417 No Hit 0.0% —
3805 KP13_01624 Dihydroneopterin triphosphate pyrophosphatase nudB AlphaFold + ColabFold –
GO:0046656The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. GO:0019177Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. GO:0008828Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate. +47 total
0.417 Hit 30.6% 1.28e-07
3806 KP13_08655 tRNA-dihydrouridine synthase A dusA AlphaFold + ColabFold
1.3.1.91
GO:0017150Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H. GO:0002943The process whereby a uridine in a transfer RNA is converted to dihydrouridine. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +58 total
0.416 Hit 32.1% 5.81e-08
3807 KP13_05545 Acetylornithine deacetylase argE AlphaFold + ColabFold
3.5.1.18
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0009014Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + succinate. +14 total
0.416 Hit 23.6% 2.21e-08
3808 KP13_05399 Succinylornithine transaminase AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +25 total
0.416 Hit 37.1% 1.90e-06
3809 KP13_04876 Spermidine/putrescine-binding periplasmic protein potD AlphaFold + ColabFold –
GO:0015846The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0019808Binding to a polyamine, an organic compound containing two or more amino groups. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
0.416 No Hit 0.0% —
3810 KP13_02629 hypothetical protein AlphaFold + ColabFold – – 0.416 No Hit 0.0% —
3811 KP13_02534 putative transposase AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.416 No Hit 0.0% —
3812 KP13_02394 hypothetical protein AlphaFold + ColabFold – – 0.416 No Hit 0.0% —
3813 KP13_01933 hypothetical protein AlphaFold + ColabFold –
GO:0046325Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell.
0.416 No Hit 0.0% —
3814 KP13_00210 rhodanese-like domain-containing protein AlphaFold + ColabFold – – 0.416 No Hit 0.0% —
3815 KP13_00202 ADP-L-glycero-D-manno-heptose-6-epimerase hldD AlphaFold + ColabFold
5.1.3.20
GO:0008712Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.416 Hit 25.4% 4.21e-06
3816 KP13_06918 hypothetical protein AlphaFold + ColabFold – – 0.415 No Hit 0.0% —
3817 KP13_05734 hypothetical protein AlphaFold + ColabFold – – 0.415 No Hit 0.0% —
3818 KP13_05378 Phosphatase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000287Binding to a magnesium (Mg) ion.
0.415 Hit 27.0% 2.23e-10
3819 KP13_05088 Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B lpsJ AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.415 Hit 49.8% 2.59e-69
3820 KP13_04383 Glycerol-3-phosphate regulon repressor AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.415 No Hit 0.0% —
3821 KP13_04191 3-deoxy-manno-octulosonate cytidylyltransferase kdsB Experimental + ColabFold
2.7.7.38
GO:0008690Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.415 No Hit 0.0% —
3822 KP13_02352 L-fucose mutarotase fucU AlphaFold + ColabFold
5.1.3.29
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0042354The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. GO:0016854Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. +69 total
0.415 Hit 47.2% 2.05e-36
3823 KP13_00398 hypothetical protein AlphaFold + ColabFold – – 0.415 No Hit 0.0% —
3824 KP13_00214 Serine acetyltransferase cysE Experimental + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0009001Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA. +14 total
0.415 No Hit 0.0% —
3825 KP13_31853 hypothetical protein AlphaFold + ColabFold – – 0.414 No Hit 0.0% —
Page of 234 · 5842 total proteins