Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3876 KP13_00953 Capsular synthesis regulator component B rcsB AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.409 No Hit 0.0% —
3877 KP13_00064 Small heat shock protein ibpB ibpB AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050821Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
0.409 No Hit 0.0% —
3878 KP13_31742 Homoserine O-succinyltransferase metA AlphaFold + ColabFold
2.3.1.46
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0019281OBSOLETE. The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine. GO:0008899Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA. +14 total
0.408 No Hit 0.0% —
3879 KP13_06847 plasmid partition protein A parA AlphaFold + ColabFold – – 0.408 No Hit 0.0% —
3880 KP13_03461 RomA protein romA AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0070290Catalysis of the reaction: an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) + H2O = an N-acylethanolamine (NAE) + a 1,2-diacyl-sn-glycero-3-phosphate + H+.
0.408 Hit 31.4% 2.75e-39
3881 KP13_02626 hypothetical protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.408 No Hit 0.0% —
3882 KP13_01391 Beta-lactamase TEM1 Experimental + ColabFold
3.5.2.6
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +14 total
0.408 No Hit 0.0% —
3883 KP13_01354 Transcription antitermination protein nusG nusG AlphaFold + ColabFold –
GO:0140673A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0032784Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. +47 total
0.408 No Hit 0.0% —
3884 KP13_01194 hypothetical protein ColabFold – – 0.408 No Hit 0.0% —
3885 KP13_00629 DNA polymerase I polA AlphaFold + ColabFold –
GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003676Binding to a nucleic acid. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +58 total
0.408 Hit 36.4% 3.63e-43
3886 KP13_04916 Aminodeoxychorismate lyase pabC AlphaFold + ColabFold
4.1.3.38
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0046656The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.407 No Hit 0.0% —
3887 KP13_04706 Formyltetrahydrofolate deformylase purU AlphaFold + ColabFold
3.5.1.10
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0008864Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+. +14 total
0.407 Hit 32.9% 2.06e-16
3888 KP13_04698 hypothetical protein AlphaFold + ColabFold – – 0.407 No Hit 0.0% —
3889 KP13_04616 putative ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.407 Hit 32.9% 3.65e-09
3890 KP13_03605 Inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.407 No Hit 0.0% —
3891 KP13_01357 hypothetical protein AlphaFold + ColabFold – – 0.406 No Hit 0.0% —
3892 KP13_32069 Stable plasmid inheritance protein flmA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.405 No Hit 0.0% —
3893 KP13_05239 D-methionine transport system substrate-binding protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.405 No Hit 0.0% —
3894 KP13_04831 Isochorismate synthase/isochorismate-pyruvate lyase mbtI mbtI AlphaFold + ColabFold –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016833Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. GO:0008909Catalysis of the reaction: chorismate = isochorismate. +25 total
0.405 No Hit 0.0% —
3895 KP13_01944 L-ribulose-5-phosphate 4-epimerase araD AlphaFold + ColabFold
5.1.3.4
GO:0019572The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose. GO:0008270Binding to a zinc ion (Zn). GO:0019569The chemical reactions and pathways resulting in the breakdown of L-arabinose into D-xylulose 5-phosphate. +36 total
0.405 No Hit 0.0% —
3896 KP13_00671 Thiosulfate sulfurtransferase glpE glpE AlphaFold + ColabFold
2.8.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0103041Catalysis of the reaction: thiosulfate + [thioredoxin]-dithiol = sulfite + 2 H+ + [thioredoxin]-disulfide + hydrogen sulfide.
0.405 No Hit 0.0% —
3897 KP13_32180 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase fklB AlphaFold + ColabFold
5.2.1.8
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
0.404 Hit 48.2% 9.45e-21
3898 KP13_05618 hypothetical protein AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.404 No Hit 0.0% —
3899 KP13_04951 hypothetical protein AlphaFold + ColabFold
3.1.1.106
GO:0061463Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate. Removes the acetyl group from either the 2'' or 3'' position of O-acetyl-ADP-ribose. GO:0001883Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose. GO:0008428Binds to and stops, prevents or reduces the activity of ribonuclease. +14 total
0.404 Hit 50.9% 6.05e-50
3900 KP13_04050 hypothetical protein ColabFold – – 0.404 No Hit 0.0% —
Page of 234 · 5842 total proteins