Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3926 KP13_00297 hypothetical protein AlphaFold + ColabFold – – 0.401 No Hit 0.0% —
3927 KP13_00063 Small heat shock protein ibpA ibpA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050821Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
0.401 No Hit 0.0% —
3928 KP13_31737 HTH-type transcriptional regulator dsdC AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.4 No Hit 0.0% —
3929 KP13_06636 hypothetical protein AlphaFold + ColabFold – – 0.4 No Hit 0.0% —
3930 KP13_04810 type IV secretion system VirB5 component AlphaFold + ColabFold – – 0.4 No Hit 0.0% —
3931 KP13_03061 putative ThiJ/PfpI family peptidase AlphaFold + ColabFold – – 0.4 No Hit 0.0% —
3932 KP13_01497 hypothetical protein AlphaFold + ColabFold – – 0.4 No Hit 0.0% —
3933 KP13_01486 Sulphatase-modifying factor domain-containing protein AlphaFold + ColabFold
2.7.11.1
GO:0120147Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O. GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
0.399 Hit 37.3% 3.40e-07
3934 KP13_02631 hypothetical protein AlphaFold + ColabFold – – 0.398 No Hit 0.0% —
3935 KP13_02519 Protein-L-isoaspartate O-methyltransferase pcm AlphaFold + ColabFold
2.1.1.77
GO:0004719Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.398 Hit 35.0% 6.73e-15
3936 KP13_01098 tRNA pseudouridine synthase B truB AlphaFold + ColabFold
5.4.99.25
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. +58 total
0.398 Hit 41.5% 3.73e-08
3937 KP13_00751 50S ribosomal protein L23 rplW AlphaFold + ColabFold –
GO:0019843Binding to a ribosomal RNA. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
0.398 Hit 35.9% 4.60e-06
3938 KP13_31813 hypothetical protein AlphaFold + ColabFold – – 0.397 No Hit 0.0% —
3939 KP13_05183 hypothetical protein AlphaFold + ColabFold – – 0.397 No Hit 0.0% —
3940 KP13_02796 Outer membrane protein tolC tolC AlphaFold + ColabFold –
GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
0.397 No Hit 0.0% —
3941 KP13_00970 hypothetical protein AlphaFold + ColabFold – – 0.397 No Hit 0.0% —
3942 KP13_00909 hypothetical protein AlphaFold + ColabFold – – 0.397 No Hit 0.0% —
3943 KP13_32058 hypothetical protein ColabFold – – 0.396 No Hit 0.0% —
3944 KP13_05516 N-carbamoyl-L-amino acid hydrolase AlphaFold + ColabFold –
GO:0016813Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.396 No Hit 0.0% —
3945 KP13_04878 Medium-chain-fatty-acid--CoA ligase alkK AlphaFold + ColabFold
6.2.1.25
GO:0018858Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate. GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
0.396 Hit 28.6% 1.05e-14
3946 KP13_03549 hypothetical protein AlphaFold + ColabFold – – 0.396 No Hit 0.0% —
3947 KP13_03306 Ferric uptake regulation protein fur Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
0.396 No Hit 0.0% —
3948 KP13_02812 putative transmembrane protein AlphaFold + ColabFold – – 0.396 No Hit 0.0% —
3949 KP13_02510 insertion element IS1 protein InsB ColabFold –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.396 No Hit 0.0% —
3950 KP13_01356 50S ribosomal protein L1 rplA AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0015934The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). +58 total
0.396 No Hit 0.0% —
Page of 234 · 5842 total proteins