Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4476 KP13_04743 Protein umuD umuD AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +25 total
No map 0.526 No Hit 0.0% —
4477 KP13_04746 DNA gyrase inhibitory protein gyrI AlphaFold + ColabFold –
GO:0008657Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.934 No Hit 0.0% —
4478 KP13_04747 Inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.571 No Hit 0.0% —
4479 KP13_04748 hypothetical protein AlphaFold + ColabFold – – No map 0.62 No Hit 0.0% —
4480 KP13_04749 Cobalamin synthase cobS AlphaFold + ColabFold
2.7.8.26
GO:0008818Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP. GO:0051073Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.489 No Hit 0.0% —
4481 KP13_04750 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase AlphaFold + ColabFold
2.4.2.21
GO:0008939Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
No map 0.256 No Hit 0.0% —
4482 KP13_04752 HPP family protein AlphaFold + ColabFold – – No map 0.221 No Hit 0.0% —
4483 KP13_04753 putative tautomerase AlphaFold + ColabFold – – No map 0.15 No Hit 0.0% —
4484 KP13_04754 putative HTH-type transcriptional regulator ltrA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.309 No Hit 0.0% —
4485 KP13_04755 Shikimate transporter shiA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.411 No Hit 0.0% —
4486 KP13_04756 hypothetical protein AlphaFold + ColabFold – – No map 0.56 No Hit 0.0% —
4487 KP13_04757 hypothetical protein AlphaFold + ColabFold – – No map 0.539 No Hit 0.0% —
4488 KP13_04759 tellurite resistance YeaR-type protein AlphaFold + ColabFold – – No map 0.513 No Hit 0.0% —
4489 KP13_04760 hypothetical protein AlphaFold + ColabFold – – No map 0.1 No Hit 0.0% —
4490 KP13_04761 Glycine cleavage system transcriptional activator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.125 No Hit 0.0% —
4491 KP13_04762 hypothetical protein AlphaFold + ColabFold – – No map 0.667 No Hit 0.0% —
4492 KP13_04764 hypothetical protein AlphaFold + ColabFold
2.7.7.65
GO:0005515Binding to a protein. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+.
No map 0.608 No Hit 0.0% —
4493 KP13_04765 hypothetical protein AlphaFold + ColabFold – – No map 0.369 No Hit 0.0% —
4494 KP13_04766 hypothetical protein AlphaFold + ColabFold – – No map 0.849 No Hit 0.0% —
4495 KP13_04767 hypothetical protein AlphaFold + ColabFold – – No map 0.53 No Hit 0.0% —
4496 KP13_04768 MATE family transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +36 total
No map 0.902 No Hit 0.0% —
4497 KP13_04769 AMP nucleosidase amn Experimental + ColabFold
3.2.2.4
GO:0044209The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis. GO:0009116The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
No map 0.712 No Hit 0.0% —
4498 KP13_04770 Signal transduction protein pmrD pmrD AlphaFold + ColabFold – – No map 0.03 No Hit 0.0% —
4499 KP13_04771 putative lysophospholipase AlphaFold + ColabFold – – No map 0.949 No Hit 0.0% —
4500 KP13_04774 putative regulatory protein TetR AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.855 No Hit 0.0% —
Page of 234 · 5842 total proteins