Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
26 KP13_03275 Succinyl-CoA ligase [ADP-forming] subunit beta sucC AlphaFold DB model + ColabFold model
6.2.1.5
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +710 total
No map 0.658 0.802 Hit 46.6% 2.88e-111
27 KP13_02757 Cystathionine beta-lyase metC AlphaFold DB model + ColabFold model –
GO:0019346The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +58 total
No map 0.712 0.519 Hit 48.6% 3.98e-111
28 KP13_03684 Ubiquinol oxidase subunit 1 cyoB AlphaFold DB model + ColabFold model
7.1.1.3
GO:0009060The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. GO:0016682Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +710 total
No map 0.999 0.998 Hit 39.1% 9.23e-109
29 KP13_05181 Glyceraldehyde-3-phosphate dehydrogenase gap AlphaFold DB model + ColabFold model –
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +25 total
No map 0.672 0.533 Hit 50.0% 1.34e-107
30 KP13_03812 Phosphoribosylformylglycinamidine cyclo-ligase purM AlphaFold DB model + ColabFold model –
GO:0004641Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
No map 0.222 0.456 Hit 49.4% 1.41e-106
31 KP13_31943 Asparagine synthetase B glutamine-hydrolyzing asnB AlphaFold DB model + ColabFold model
6.3.5.4
GO:0004066Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. GO:0006529OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.973 0.995 Hit 37.5% 1.28e-102
32 KP13_02991 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase gpmA AlphaFold DB model + ColabFold model
5.4.2.11
GO:0016868Catalysis of the transfer of a phosphate group from one position to another within a single molecule. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. +25 total
No map 0.808 0.181 Hit 58.1% 3.47e-101
33 KP13_04181 Aspartate aminotransferase aspC AlphaFold DB model + ColabFold model
2.6.1.-
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. +710 total
No map 0.913 0.431 Hit 42.7% 6.22e-101
34 KP13_31481 Fumarate reductase flavoprotein subunit frdA AlphaFold DB model + ColabFold model
1.3.5.1
GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009061The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor. +69 total
No map 0.975 0.997 Hit 44.0% 2.57e-100
35 KP13_00391 Tyrosine aminotransferase tyrB AlphaFold DB model + ColabFold model
2.6.1.-
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. +69 total
No map 0.907 0.915 Hit 41.0% 9.53e-100
36 KP13_04374 Aromatic-amino-acid aminotransferase AlphaFold DB model + ColabFold model
2.6.1.-
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. +69 total
No map 0.895 0.573 Hit 40.8% 5.88e-99
37 KP13_02995 UDP-glucose 4-epimerase galE AlphaFold DB model + ColabFold model
5.1.3.2
GO:0003978Catalysis of the reaction: UDP-glucose = UDP-galactose. GO:0006012The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.968 0.706 Hit 60.4% 9.88e-99
38 KP13_03276 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex sucB AlphaFold DB model + ColabFold model
2.3.1.61
GO:0045252A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +36 total
No map 0.208 0.683 Hit 58.2% 7.31e-98
39 KP13_04212 Replication-associated recombination protein A AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. +58 total
No map 0.783 0.862 Hit 41.1% 1.71e-97
40 KP13_03954 S-formylglutathione hydrolase frmB AlphaFold DB model + ColabFold model
3.1.2.12
GO:0018738Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+. GO:0046294The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.587 0.417 Hit 54.0% 5.84e-97
41 KP13_02286 Thymidylate synthase thyA AlphaFold DB model + ColabFold model
2.1.1.45
GO:0016741Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). GO:0004799Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. GO:0006231The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). +36 total
No map 0.956 0.307 Hit 50.7% 8.93e-96
42 KP13_04661 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.875 0.647 Hit 44.4% 2.52e-95
43 KP13_00029 Glucosamine--fructose-6-phosphate aminotransferase isomerizing glmS AlphaFold DB model + ColabFold model
2.6.1.16
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. GO:0004360Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. +710 total
No map 0.712 0.989 Hit 40.9% 4.81e-94
44 KP13_03021 Urocanate hydratase hutU AlphaFold DB model + ColabFold model
4.2.1.49
GO:0016153Catalysis of the reaction: 4-imidazolone-5-propanoate + H+ = trans-urocanate + H2O. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0019556OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide. +14 total
No map 0.969 0.817 Hit 34.8% 1.40e-93
45 KP13_00870 GMP synthase guaA AlphaFold DB model + ColabFold model –
GO:0006164The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0003922Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +25 total
No map 0.918 0.019 Hit 36.5% 2.23e-93
46 KP13_05055 S-formylglutathione hydrolase AlphaFold DB model + ColabFold model
3.1.2.12
GO:0018738Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+. GO:0046294The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.355 0.324 Hit 53.6% 2.27e-92
47 KP13_02993 Galactokinase galK AlphaFold DB model + ColabFold model
2.7.1.6
GO:0006012The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). +69 total
No map 0.926 0.395 Hit 43.8% 1.29e-91
48 KP13_01611 Glucose-6-phosphate 1-dehydrogenase zwf AlphaFold DB model + ColabFold model
1.1.1.49
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0006006The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +36 total
No map 0.538 0.696 Hit 38.3% 1.11e-88
49 KP13_00570 Cystathionine gamma-synthase metB AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019346The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. +47 total
No map 0.636 0.835 Hit 41.9% 1.26e-88
50 KP13_31528 Threonyl-tRNA synthetase thrS AlphaFold DB model + ColabFold model –
GO:0004829Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
No map 0.858 0.204 Hit 40.9% 7.59e-88
Page of 234 · 5842 total proteins