Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
26 KP13_32366 putative reverse transcriptase AlphaFold + ColabFold –
GO:0003964Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time.
0.062 No Hit 0.0% —
27 KP13_32365 transposase for insertion sequence-like element IS431mec AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
0.584 No Hit 0.0% —
28 KP13_32361 hypothetical protein ColabFold – – 0.956 No Hit 0.0% —
29 KP13_32345 SbmA sbmA AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. +25 total
0.988 No Hit 0.0% —
30 KP13_32248 Beta-lactamase SHV-12 Experimental + ColabFold
3.5.2.6
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +14 total
0.996 No Hit 0.0% —
31 KP13_32246 Streptothricin acetyltransferase sat ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.515 No Hit 0.0% —
32 KP13_32245 N-acetylmuramoyl-L-alanine amidase AmiC amiC AlphaFold + ColabFold
3.5.1.28
GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008745Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
0.771 No Hit 0.0% —
33 KP13_32244 multidrug efflux protein EmrE emrE AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +58 total
0.928 No Hit 0.0% —
34 KP13_32243 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
35 KP13_32242 Type II secretion system protein E AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.487 No Hit 0.0% —
36 KP13_32241 putative transposase AlphaFold + ColabFold – – 0.074 No Hit 0.0% —
37 KP13_32240 putative HTH transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.463 No Hit 0.0% —
38 KP13_32238 Ethanolamine ammonia-lyase heavy chain eutB AlphaFold + ColabFold
4.3.1.7
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0008851Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
0.293 No Hit 0.0% —
39 KP13_32234 DNA repair protein UmuC AlphaFold + ColabFold –
GO:0003684Binding to damaged DNA. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
0.707 No Hit 0.0% —
40 KP13_32233 phage terminase, small subunit, P27 family ColabFold – – 0.496 No Hit 0.0% —
41 KP13_32232 Formate dehydrogenase, nitrate-inducible, major subunit fdnG ColabFold –
GO:0047111Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0008863Catalysis of the reaction: formate + NAD+ = CO2 + NADH. +1013 total
0.928 No Hit 0.0% —
42 KP13_32231 Formate dehydrogenase-O major subunit fdoG ColabFold –
GO:0047111Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0008863Catalysis of the reaction: formate + NAD+ = CO2 + NADH. +1013 total
0.932 No Hit 0.0% —
43 KP13_32230 Formate dehydrogenase H ColabFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0008863Catalysis of the reaction: formate + NAD+ = CO2 + NADH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +710 total
0.855 No Hit 0.0% —
44 KP13_32222 Transposase for insertion sequence-like element IS431mec AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.584 No Hit 0.0% —
45 KP13_32221 D-aminoacylase dan Experimental + ColabFold –
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.494 No Hit 0.0% —
46 KP13_32220 Osmotically-inducible protein Y osmY AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.112 No Hit 0.0% —
47 KP13_32218 Transcription termination factor rho rho AlphaFold + ColabFold
3.6.4.-
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003676Binding to a nucleic acid. GO:0008186Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. +69 total
0.332 No Hit 0.0% —
48 KP13_32214 putative lipoprotein AlphaFold + ColabFold – – 0.568 No Hit 0.0% —
49 KP13_32211 transcription elongation factor GreB AlphaFold + ColabFold –
GO:0032784Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. GO:0070063Binding to an RNA polymerase molecule or complex. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
0.419 No Hit 0.0% —
50 KP13_32209 hypothetical protein ColabFold – – 0.583 No Hit 0.0% —
Page of 234 · 5842 total proteins