Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
476 KP13_31482 Stationary-phase-induced ribosome-associated protein sra AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
No map 0.09 No Hit 0.0% —
477 KP13_26424 Orotidine 5'-phosphate decarboxylase pyrF Experimental + ColabFold model
4.1.1.23
GO:0044205The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen. GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0004590Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP. +14 total
No map 0.65 No Hit 0.0% —
478 KP13_26403 Phosphatidylglycerophosphatase B pgpB AlphaFold DB model + ColabFold model
3.6.1.27
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050380Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate.
No map 0.981 No Hit 0.0% —
479 KP13_24850 Dihydroorotase pyrC AlphaFold DB model + ColabFold model –
GO:0016812Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. GO:0004151Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+. GO:0019856The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. +14 total
No map 0.304 No Hit 0.0% —
480 KP13_20988 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.872 No Hit 0.0% —
481 KP13_20969 GtrA family protein AlphaFold DB model + ColabFold model –
GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.563 No Hit 0.0% —
482 KP13_20435 7-cyano-7-deazaguanine synthase queC AlphaFold DB model + ColabFold model
6.3.4.20
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016879Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0008270Binding to a zinc ion (Zn). +14 total
No map 0.539 No Hit 0.0% —
483 KP13_20430 extracellular solute-binding protein AlphaFold DB model + ColabFold model –
GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.794 No Hit 0.0% —
484 KP13_19559 HTH-type transcriptional regulator betI AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +25 total
No map 0.713 No Hit 0.0% —
485 KP13_18568 Adenine deaminase ade AlphaFold DB model + ColabFold model
3.5.4.2
GO:0006146The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. GO:0000034Catalysis of the reaction: adenine + H+ + H2O = hypoxanthine + NH4+. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +14 total
No map 0.865 No Hit 0.0% —
486 KP13_18328 aminoglycoside adenylyltransferase aadA2 AlphaFold DB model + ColabFold model
2.7.7.47
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0070566Catalysis of the transfer of an adenylyl group to an acceptor. +25 total
No map 0.206 No Hit 0.0% —
487 KP13_18323 Chloramphenicol resistance protein cmlA1 AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
No map 0.951 No Hit 0.0% —
488 KP13_17708 putative transpeptidase AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +25 total
No map 0.318 No Hit 0.0% —
489 KP13_16917 ATP-dependent DNA helicase rep rep AlphaFold DB model + ColabFold model
5.6.2.4
GO:0006268OBSOLETE. The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +1013 total
No map 0.51 No Hit 0.0% —
490 KP13_16845 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein AlphaFold DB model + ColabFold model – – No map 0.627 No Hit 0.0% —
491 KP13_16560 S-ribosylhomocysteine lyase luxS AlphaFold DB model + ColabFold model
4.4.1.21
GO:0043768Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine. GO:0005506Binding to an iron (Fe) ion. GO:0046872Binding to a metal ion. +14 total
No map 0.563 No Hit 0.0% —
492 KP13_16529 Transport-associated and nodulation domain-containing protein AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.829 No Hit 0.0% —
493 KP13_16511 Regulatory protein recX recX AlphaFold DB model + ColabFold model –
GO:0006282Any process that modulates the frequency, rate or extent of DNA repair. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.194 No Hit 0.0% —
494 KP13_16463 Membrane-bound lytic murein transglycosylase B mltB AlphaFold DB model + ColabFold model –
GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.
No map 0.628 No Hit 0.0% —
495 KP13_16268 putative phage integrase AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.64 No Hit 0.0% —
496 KP13_16086 3,4-dihydroxyphenylacetate 2,3-dioxygenase hpcB AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008198Binding to a ferrous iron ion, Fe(II). GO:0008687Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H+. +14 total
No map 0.714 No Hit 0.0% —
497 KP13_16060 Alanine racemase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
No map 0.147 No Hit 0.0% —
498 KP13_16038 N-acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.194 No Hit 0.0% —
499 KP13_16022 DNA replication protein dnaC AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:1990077Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. +36 total
No map 0.162 No Hit 0.0% —
500 KP13_15795 putative diguanylate cyclase AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
No map 0.986 No Hit 0.0% —
Page of 234 · 5842 total proteins