Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4976 KP13_02377 tRNA pseudouridine synthase C truC AlphaFold + ColabFold
5.4.99.26
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. +47 total
0.088 Hit 29.9% 1.35e-14
4977 KP13_03005 hypothetical protein AlphaFold + ColabFold – – 0.087 No Hit 0.0% —
4978 KP13_04863 Phosphatase nudJ nudJ AlphaFold + ColabFold
3.6.1.-
GO:0017111Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. GO:0004787Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate. GO:0017110Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. +14 total
0.086 Hit 28.4% 3.26e-06
4979 KP13_04140 hypothetical protein AlphaFold + ColabFold –
GO:0046872Binding to a metal ion.
0.086 No Hit 0.0% —
4980 KP13_02975 p-hydroxybenzoic acid efflux pump subunit aaeA aaeA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.086 No Hit 0.0% —
4981 KP13_31576 Multidrug resistance protein A AlphaFold + ColabFold –
GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.085 No Hit 0.0% —
4982 KP13_04398 putative ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.085 Hit 40.3% 1.11e-06
4983 KP13_02099 putative isochorismatase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.085 No Hit 0.0% —
4984 KP13_04131 hypothetical protein AlphaFold + ColabFold – – 0.084 No Hit 0.0% —
4985 KP13_01419 hypothetical protein AlphaFold + ColabFold – – 0.084 No Hit 0.0% —
4986 KP13_04589 Coenzyme PQQ synthesis protein B pqqB AlphaFold + ColabFold –
GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed.
0.083 No Hit 0.0% —
4987 KP13_04463 Putative ABC transporter periplasmic-binding protein AlphaFold + ColabFold –
GO:0015846The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0019808Binding to a polyamine, an organic compound containing two or more amino groups. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
0.083 No Hit 0.0% —
4988 KP13_00871 Putative prophage CPS-53 integrase intS AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.083 No Hit 0.0% —
4989 KP13_00654 putative N-acetyltransferase AlphaFold + ColabFold
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.083 No Hit 0.0% —
4990 KP13_31795 hypothetical protein AlphaFold + ColabFold – – 0.082 No Hit 0.0% —
4991 KP13_03991 hypothetical protein AlphaFold + ColabFold – – 0.082 No Hit 0.0% —
4992 KP13_01543 hypothetical protein AlphaFold + ColabFold – – 0.081 No Hit 0.0% —
4993 KP13_32023 hypothetical protein AlphaFold + ColabFold – – 0.08 No Hit 0.0% —
4994 KP13_00878 Prophage CP4-57 regulatory protein AlphaFold + ColabFold – – 0.08 No Hit 0.0% —
4995 KP13_32145 hypothetical protein AlphaFold + ColabFold – – 0.079 No Hit 0.0% —
4996 KP13_02393 6-carboxy-5,6,7,8-tetrahydropterin synthase queD AlphaFold + ColabFold
4.-.-.-
GO:0070497Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+. GO:0046872Binding to a metal ion. GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.
0.079 Hit 37.1% 9.67e-12
4997 KP13_02169 D-3-phosphoglycerate dehydrogenase serA AlphaFold + ColabFold
1.1.1.399 1.1.1.95
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.079 Hit 41.3% 9.22e-06
4998 KP13_00802 Autonomous glycyl radical cofactor grcA AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008861Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate.
0.079 No Hit 0.0% —
4999 KP13_00779 Ribosomal RNA small subunit methyltransferase B rsmB AlphaFold + ColabFold
2.1.1.176
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
0.079 Hit 34.5% 2.37e-23
5000 KP13_03341 Rare lipoprotein A rlpA AlphaFold + ColabFold
4.2.2.-
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +47 total
0.078 No Hit 0.0% —
Page of 208 · 5192 total proteins