Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4976 KP13_05441 NAD(P)-binding domain-containing protein AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.
0.918 No Hit 0.0% —
4977 KP13_05442 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.827 No Hit 0.0% —
4978 KP13_05443 hypothetical protein ColabFold – – 0.541 No Hit 0.0% —
4979 KP13_05446 MF family transporter AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.997 No Hit 0.0% —
4980 KP13_05447 Psp operon transcriptional activator pspF AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.147 No Hit 0.0% —
4981 KP13_05448 Phage shock protein A pspA AlphaFold + ColabFold – – 0.762 No Hit 0.0% —
4982 KP13_05449 Phage shock protein B pspB AlphaFold + ColabFold –
GO:0009271A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.199 No Hit 0.0% —
4983 KP13_05450 Phage shock protein C pspC AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.744 No Hit 0.0% —
4984 KP13_05451 Phage shock protein D pspD AlphaFold + ColabFold – – 0.584 No Hit 0.0% —
4985 KP13_05452 putative ATP-binding protein AlphaFold + ColabFold – – 0.912 No Hit 0.0% —
4986 KP13_05453 hypothetical protein AlphaFold + ColabFold – – 0.602 No Hit 0.0% —
4987 KP13_05454 HTH-type transcriptional regulator dsdC dsdC AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.382 No Hit 0.0% —
4988 KP13_05455 putative 6-phospho-beta-glucosidase AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
0.089 No Hit 0.0% —
4989 KP13_05456 Transcriptional regulatory protein tyrR tyrR AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +25 total
0.71 No Hit 0.0% —
4990 KP13_05457 Protein abrB abrB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0010468Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
0.852 No Hit 0.0% —
4991 KP13_05458 Thiol peroxidase tpx AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008379Catalysis of the reaction: [thioredoxin]-dithiol + H2O2 = [thioredoxin]-disulfide + H2O. GO:0016684Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. +14 total
0.571 No Hit 0.0% —
4992 KP13_05459 L-Ala-D/L-Glu epimerase AlphaFold + ColabFold
5.1.1.-
GO:0016855Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0046872Binding to a metal ion.
0.931 No Hit 0.0% —
4993 KP13_05460 Protein mpaA mpaA AlphaFold + ColabFold
3.4.17.-
GO:0008270Binding to a zinc ion (Zn). GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +69 total
0.927 No Hit 0.0% —
4994 KP13_05461 Periplasmic murein peptide-binding protein mppA AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
0.891 No Hit 0.0% —
4995 KP13_05462 hypothetical protein AlphaFold + ColabFold – – 0.702 No Hit 0.0% —
4996 KP13_05463 hypothetical protein ColabFold – – 0.58 No Hit 0.0% —
4997 KP13_05464 hypothetical protein ColabFold – – 0.362 No Hit 0.0% —
4998 KP13_05468 ABC superfamily ATP binding cassette transporter AlphaFold + ColabFold –
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
0.223 No Hit 0.0% —
4999 KP13_05469 putative ABC transporter permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.712 No Hit 0.0% —
5000 KP13_05471 TenA family transcription regulator AlphaFold + ColabFold
3.5.99.2
GO:0050334Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+. GO:0006772The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.648 No Hit 0.0% —
Page of 234 · 5842 total proteins