Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
651 KP13_05217 Methionine aminopeptidase AlphaFold DB model + ColabFold model
3.4.11.18
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0070006Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.937 0.315 Hit 44.3% 1.35e-59
652 KP13_05061 putative sensor histidine protein kinase AlphaFold DB model + ColabFold model –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
No map 0.937 0.825 No Hit 0.0% —
653 KP13_04492 hypothetical protein AlphaFold DB model + ColabFold model
1.-.-.-
GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
No map 0.937 0.643 No Hit 0.0% —
654 KP13_04457 putative protease AlphaFold DB model + ColabFold model –
GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map 0.937 0.687 No Hit 0.0% —
655 KP13_04437 S-(hydroxymethyl)glutathione dehydrogenase AlphaFold DB model + ColabFold model
1.1.1.284
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006069OBSOLETE. An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. GO:0008270Binding to a zinc ion (Zn). +710 total
No map 0.937 0.288 Hit 67.3% 4.95e-46
656 KP13_03849 Ethanolamine utilization protein eutJ eutJ AlphaFold DB model + ColabFold model – – No map 0.937 0.966 No Hit 0.0% —
657 KP13_03526 Inositol 2-dehydrogenase idhA AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
No map 0.937 0.902 No Hit 0.0% —
658 KP13_03166 Sugar-binding domain-containing protein AlphaFold DB model + ColabFold model –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.937 0.466 No Hit 0.0% —
659 KP13_02864 Ribosomal RNA large subunit methyltransferase G rlmG AlphaFold DB model + ColabFold model
2.1.1.174
GO:0031167The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. +58 total
No map 0.937 0.765 No Hit 0.0% —
660 KP13_02065 putative amidohydrolase AlphaFold DB model + ColabFold model –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
No map 0.937 0.886 No Hit 0.0% —
661 KP13_02019 putative acyl transferase AlphaFold DB model + ColabFold model –
GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
No map 0.937 0.954 No Hit 0.0% —
662 KP13_01975 Riboflavin biosynthesis protein ribF ribF AlphaFold DB model + ColabFold model –
GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). GO:0003919Catalysis of the reaction: ATP + FMN = diphosphate + FAD. GO:0008531Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+. +36 total
No map 0.937 0.387 No Hit 0.0% —
663 KP13_01946 RNA polymerase-associated protein rapA rapA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140658An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.937 0.891 Hit 28.5% 1.87e-07
664 KP13_01200 Extracellular solute-binding protein AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
No map 0.937 0.877 No Hit 0.0% —
665 KP13_00556 N-acetyl-gamma-glutamyl-phosphate reductase argC AlphaFold DB model + ColabFold model
1.2.1.38
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. +58 total
No map 0.937 0.239 No Hit 0.0% —
666 KP13_00359 Sodium/bile acid symporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.937 0.954 Hit 30.2% 1.36e-17
667 KP13_00046 Inner membrane protein oxaA oxaA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0032977Binds transmembrane domain-containing proteins and mediates their integration into a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.937 0.913 Hit 27.5% 2.25e-12
668 KP13_31508 putative cystathionine-beta-synthase AlphaFold DB model + ColabFold model –
GO:0006535OBSOLETE. The chemical reactions and pathways resulting in the formation of cysteine from L- serine.
No map 0.936 0.574 Hit 54.3% 7.60e-25
669 KP13_16520 Alanyl-tRNA synthetase alaS AlphaFold DB model + ColabFold model
6.1.1.7
GO:0006419The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +1013 total
No map 0.936 0.183 Hit 58.1% 1.88e-10
670 KP13_06748 DNA topoisomerase III AlphaFold DB model + ColabFold model
5.6.2.1
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. GO:0003917Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. +69 total
No map 0.936 0.564 Hit 22.3% 3.55e-10
671 KP13_05460 Protein mpaA mpaA AlphaFold DB model + ColabFold model
3.4.17.-
GO:0008270Binding to a zinc ion (Zn). GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +69 total
No map 0.936 0.927 No Hit 0.0% —
672 KP13_02362 putative monooxygenase AlphaFold DB model + ColabFold model –
GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
No map 0.936 0.356 No Hit 0.0% —
673 KP13_01960 Dihydrofolate reductase folA AlphaFold DB model + ColabFold model
1.5.1.3
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0004146Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. GO:0046654The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. +69 total
No map 0.936 0.615 Hit 27.5% 1.86e-11
674 KP13_01700 putative UDP-N-acetyl-D-mannosaminuronic acid transferase wecG AlphaFold DB model + ColabFold model
2.4.1.180
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. +25 total
No map 0.936 0.308 No Hit 0.0% —
675 KP13_01636 putative symporter AlphaFold DB model + ColabFold model –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +14 total
No map 0.936 0.703 No Hit 0.0% —
Page of 234 · 5842 total proteins