Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
626 KP13_01847 General secretion pathway protein N pulN AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.940 0.904 No Hit 0.0% —
627 KP13_01803 Regulator of sigma E protease rseP AlphaFold DB model + ColabFold model
3.4.24.-
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. +36 total
No map 0.940 0.911 No Hit 0.0% —
628 KP13_01633 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.940 0.601 No Hit 0.0% —
629 KP13_01338 Helicase superfamily protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140658An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. +14 total
No map 0.940 0.883 Hit 36.1% 7.57e-08
630 KP13_00929 Major facilitator superfamily MFS-1 protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.940 0.851 No Hit 0.0% —
631 KP13_00116 PTS system N-acetylmuramic acid-specific EIIBC component murP AlphaFold DB model + ColabFold model
2.7.1.192
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +36 total
No map 0.940 0.791 No Hit 0.0% —
632 KP13_31946 putative transcription regulator AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.939 0.97 No Hit 0.0% —
633 KP13_05659 chitinase II chiA1 Experimental + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0008061Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
No map 0.939 0.339 Hit 36.8% 3.45e-07
634 KP13_03660 Acyl-CoA thioesterase 2 tesB AlphaFold DB model + ColabFold model
3.1.2.20
GO:0006637The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.939 0.359 Hit 50.0% 1.30e-07
635 KP13_03596 Outer membrane protein C AlphaFold DB model + ColabFold model – – No map 0.939 0.159 No Hit 0.0% —
636 KP13_03427 High-affinity choline transport protein betT AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
No map 0.939 0.683 No Hit 0.0% —
637 KP13_03371 Carbohydrate/purine kinase domain-containing protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
No map 0.939 0.585 Hit 25.0% 1.35e-06
638 KP13_02712 FAD-dependent pyridine nucleotide-disulfide oxidoreductase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.939 0.109 Hit 26.6% 1.22e-29
639 KP13_01870 Spermidine synthase speE AlphaFold DB model + ColabFold model
2.5.1.16
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004766Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. +14 total
No map 0.939 0.951 Hit 44.0% 3.65e-26
640 KP13_00833 NAGC-like transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006351The synthesis of an RNA transcript from a DNA template.
No map 0.939 0.349 Hit 26.5% 5.01e-14
641 KP13_00806 RNA polymerase sigma-E factor rpoE AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +47 total
No map N/A 0.939 No Hit 0.0% —
642 KP13_00487 Anaerobic C4-dicarboxylate transporter dcuA dcuA AlphaFold DB model + ColabFold model –
GO:0015740The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015556Enables the transfer of C4-dicarboxylate from one side of a membrane to the other. +14 total
No map 0.939 0.813 No Hit 0.0% —
643 KP13_00081 Acetolactate synthase isozyme 1 large subunit ilvB AlphaFold DB model + ColabFold model
2.2.1.6
GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0003984Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate. GO:0000287Binding to a magnesium (Mg) ion. +69 total
No map 0.939 0.998 Hit 34.3% 3.06e-12
644 KP13_05596 putative oxidoreductase AlphaFold DB model + ColabFold model
1.3.1.104
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0141148Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NADP+ = a (2E)-enoyl-[ACP] + H+ + NADPH. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
No map 0.938 0.223 Hit 28.4% 4.77e-25
645 KP13_05397 N-succinylglutamate 5-semialdehyde dehydrogenase AlphaFold DB model + ColabFold model
1.2.1.71
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +36 total
No map 0.938 0.901 Hit 34.4% 1.37e-06
646 KP13_04414 1-phosphofructokinase fruK AlphaFold DB model + ColabFold model –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
No map 0.938 0.238 No Hit 0.0% —
647 KP13_04320 putative ATP-dependent helicase dinG dinG AlphaFold DB model + ColabFold model
5.6.2.3
GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0003676Binding to a nucleic acid. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +1114 total
No map 0.938 0.659 No Hit 0.0% —
648 KP13_03480 putative oxidoreductase AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.938 0.767 Hit 29.0% 1.49e-06
649 KP13_03143 putative chaperone protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140662Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
No map 0.938 0.316 Hit 24.8% 8.11e-06
650 KP13_01927 Inner membrane transport protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.938 0.403 No Hit 0.0% —
Page of 234 · 5842 total proteins