Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
851 KP13_03519 Sucrose-6-phosphate hydrolase scrB AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +14 total
0.881 No Hit 0.0% —
852 KP13_02492 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, HpaG1subunit AlphaFold + ColabFold –
GO:0018800Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. GO:0008704Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
0.881 Hit 30.5% 4.86e-16
853 KP13_01326 putative sn-glycerol-3-phosphate transport system permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.881 No Hit 0.0% —
854 KP13_01170 Spermidine export protein mdtI mdtI AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015848The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.881 No Hit 0.0% —
855 KP13_00002 putative transport protein hsrA hsrA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.881 No Hit 0.0% —
856 KP13_05351 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.88 No Hit 0.0% —
857 KP13_05114 Oligopeptide ABC transport system permease component AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.88 No Hit 0.0% —
858 KP13_05034 Aminobenzoyl-glutamate transport protein abgT AlphaFold + ColabFold –
GO:0015558Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid. GO:1902604The directed movement of N-(4-aminobenzoyl)-L-glutamate across a membrane.
0.88 No Hit 0.0% —
859 KP13_03906 Short-chain dehydrogenase/reductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.88 Hit 47.8% 4.16e-07
860 KP13_02427 Cytochrome c assembly protein AlphaFold + ColabFold –
GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.88 No Hit 0.0% —
861 KP13_00643 High-affinity branched-chain amino acid transport ATP-binding protein livG livG AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
0.88 Hit 31.0% 7.06e-25
862 KP13_00435 Proton glutamate symport protein gltP AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006835The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.88 Hit 44.2% 5.54e-08
863 KP13_04468 hypothetical protein AlphaFold + ColabFold – – 0.879 No Hit 0.0% —
864 KP13_00875 hypothetical protein ColabFold – – 0.879 No Hit 0.0% —
865 KP13_04949 Glucans biosynthesis protein C mdoC AlphaFold + ColabFold
2.1.-.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016741Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.878 No Hit 0.0% —
866 KP13_04808 Type IV secretion system protein virB6 virB6 AlphaFold + ColabFold –
GO:0030255The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.878 No Hit 0.0% —
867 KP13_04763 Non-heme chloroperoxidase cpo AlphaFold + ColabFold – – 0.878 Hit 30.4% 8.76e-06
868 KP13_03312 hypothetical protein AlphaFold + ColabFold – – 0.878 No Hit 0.0% —
869 KP13_00849 Chaperone protein hscA hscA AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +36 total
0.878 Hit 44.1% 6.37e-18
870 KP13_00370 Maltose transport system permease protein malG malG AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.878 No Hit 0.0% —
871 KP13_32093 Insertion sequence IS408 putative ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.877 No Hit 0.0% —
872 KP13_05308 Heme exporter protein C ccmC AlphaFold + ColabFold –
GO:0015232Enables the transfer of heme from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015886The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.877 No Hit 0.0% —
873 KP13_03430 Choline dehydrogenase betA AlphaFold + ColabFold
1.1.99.1 1.2.1.8
GO:0019285The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline. GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0008812Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde. +36 total
0.877 Hit 47.8% 4.62e-171
874 KP13_01200 Extracellular solute-binding protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.877 No Hit 0.0% —
875 KP13_31770 intracellular growth attenuator protein IgaA igaA Experimental + AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.876 No Hit 0.0% —
Page of 234 · 5842 total proteins