Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
826 KP13_03434 putative ABC transport system permease component AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.886 No Hit 0.0% —
827 KP13_02776 Inner membrane protein AlphaFold + ColabFold – – 0.886 No Hit 0.0% —
828 KP13_02065 putative amidohydrolase AlphaFold + ColabFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.886 No Hit 0.0% —
829 KP13_01903 D-alanine--D-alanine ligase B ddlB AlphaFold + ColabFold
6.3.2.4
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008716Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H+ + phosphate. GO:0046872Binding to a metal ion. +58 total
0.886 No Hit 0.0% —
830 KP13_01101 Transcription elongation protein nusA nusA AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +69 total
0.886 No Hit 0.0% —
831 KP13_00115 putative inner membrane transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.886 No Hit 0.0% —
832 KP13_05013 hypothetical protein AlphaFold + ColabFold – – 0.885 No Hit 0.0% —
833 KP13_04830 Major facilitator superfamily domain-containing protein 3 mfsD3 AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.885 Hit 28.2% 2.26e-06
834 KP13_04512 Respiratory nitrate reductase 2 alpha chain narZ AlphaFold + ColabFold
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +811 total
0.885 No Hit 0.0% —
835 KP13_02780 GCN5-related N-acetyltransferase (GNAT) domain-containing protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.885 No Hit 0.0% —
836 KP13_05403 TVP38/TMEM64 family inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.884 No Hit 0.0% —
837 KP13_05638 hypothetical protein ColabFold – – 0.883 No Hit 0.0% —
838 KP13_04667 putative H+/gluconate symporter AlphaFold + ColabFold – – 0.883 No Hit 0.0% —
839 KP13_04022 hypothetical protein AlphaFold + ColabFold – – 0.883 No Hit 0.0% —
840 KP13_02676 hypothetical protein AlphaFold + ColabFold – – 0.883 No Hit 0.0% —
841 KP13_02274 hypothetical protein AlphaFold + ColabFold – – 0.883 No Hit 0.0% —
842 KP13_01900 Cell division protein ftsZ ftsZ Experimental + ColabFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate.
0.883 No Hit 0.0% —
843 KP13_01338 Helicase superfamily protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140658An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. +14 total
0.883 Hit 36.1% 7.57e-08
844 KP13_03512 Secretion protein HlyD family AlphaFold + ColabFold – – 0.882 No Hit 0.0% —
845 KP13_02246 Putative oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.882 Hit 24.2% 1.25e-09
846 KP13_01766 Ribose transport system permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.882 No Hit 0.0% —
847 KP13_01524 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.882 No Hit 0.0% —
848 KP13_31780 hypothetical protein ColabFold – – 0.881 No Hit 0.0% —
849 KP13_03783 O-antigen export system ATP-binding protein rfbB rfbB AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +14 total
0.881 Hit 33.5% 5.68e-26
850 KP13_03747 Inner membrane protein AlphaFold + ColabFold
2.7.13.3
GO:0004673Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
0.881 No Hit 0.0% —
Page of 234 · 5842 total proteins