Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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155 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
76 KP13_04340 OmpA/MotB domain-containing protein Experimental + AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
0.656 No Hit 0.0% —
77 KP13_01954 LPS-assembly protein lptD lptD Experimental + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015920The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. +47 total
0.656 No Hit 0.0% —
78 KP13_26424 Orotidine 5'-phosphate decarboxylase pyrF Experimental + ColabFold
4.1.1.23
GO:0044205The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen. GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0004590Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP. +14 total
0.65 No Hit 0.0% —
79 KP13_31877 hypothetical protein Experimental + ColabFold – – 0.634 No Hit 0.0% —
80 KP13_01466 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE Experimental + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0050515Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H+.
0.628 No Hit 0.0% —
81 KP13_14582 D-alanine--D-alanine ligase A ddlA Experimental + ColabFold
6.3.2.4
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008716Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H+ + phosphate. GO:0046872Binding to a metal ion. +58 total
0.627 No Hit 0.0% —
82 KP13_31537 Cytidine deaminase cdd Experimental + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0009972OBSOLETE. The removal of amino group in the presence of water. +25 total
0.587 Hit 33.0% 8.18e-10
83 KP13_01236 Bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase cpdB Experimental + ColabFold –
GO:0009166The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). GO:0009117The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +47 total
0.579 Hit 26.8% 3.01e-08
84 KP13_03824 Dihydrodipicolinate synthase Experimental + ColabFold
4.3.3.7
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+. +25 total
0.574 Hit 29.2% 4.76e-22
85 KP13_31847 putative acyl-CoA N-acyltransferase Experimental + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.557 No Hit 0.0% —
86 KP13_00681 Carboxylesterase bioH bioH Experimental + ColabFold –
GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0052689Catalysis of the hydrolysis of a carboxylic ester bond.
0.553 Hit 30.2% 2.30e-06
87 KP13_02256 Sucrose operon repressor cscR Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.545 No Hit 0.0% —
88 KP13_02819 Urease accessory protein ureF ureF Experimental + ColabFold –
GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0016151Binding to a nickel (Ni) cation.
0.543 No Hit 0.0% —
89 KP13_31885 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA Experimental + ColabFold
2.6.1.62
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0004015Catalysis of the reaction: (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = S-adenosyl-4-methylsulfanyl-2-oxobutanoate + (7R,8S)-7,8-diammoniononanoate. +36 total
0.536 Hit 29.7% 9.59e-36
90 KP13_01007 GST-like protein Experimental + ColabFold – – 0.534 Hit 36.6% 2.26e-14
91 KP13_05433 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI Experimental + ColabFold
1.3.1.9
GO:0004318Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
0.532 Hit 30.9% 2.07e-07
92 KP13_02877 hypothetical protein Experimental + ColabFold – – 0.53 No Hit 0.0% —
93 KP13_01763 Glutathione transferase fosA fosA Experimental + ColabFold – – 0.53 No Hit 0.0% —
94 KP13_05482 Hydantoin racemase hyuE Experimental + ColabFold –
GO:0036361OBSOLETE. Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
0.515 No Hit 0.0% —
95 KP13_31521 3-phosphoshikimate 1-carboxyvinyltransferase aroA Experimental + ColabFold
2.5.1.19
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0003866Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate. GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). +47 total
0.506 No Hit 0.0% —
96 KP13_05551 Periplasmic binding protein/LacI transcriptional regulator family protein Experimental + ColabFold – – 0.5 No Hit 0.0% —
97 KP13_32221 D-aminoacylase dan Experimental + ColabFold –
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.494 No Hit 0.0% —
98 KP13_02814 Urease subunit gamma ureA Experimental + ColabFold
3.5.1.5
GO:0043419The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. GO:0009039Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+. GO:0016151Binding to a nickel (Ni) cation. +25 total
0.492 No Hit 0.0% —
99 KP13_01769 putative ribose ABC transporter substrate-binding protein Experimental + ColabFold – – 0.484 No Hit 0.0% —
100 KP13_00972 Nucleoside triphosphatase nudI nudI Experimental + ColabFold
3.6.1.9 3.6.1.12 3.6.1.- +14 total
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0047840Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate. +25 total
0.472 No Hit 0.0% —
Page of 7 · 155 total proteins