Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1301 KP13_05486 putative membrane protein AlphaFold DB model + ColabFold model – – No map N/A 0.857 No Hit 0.0% —
1302 KP13_03745 putative aminotransferase AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
No map 0.857 0.967 Hit 28.6% 1.10e-16
1303 KP13_03565 Rhizopine catabolism protein mocC mocC AlphaFold DB model + ColabFold model – – No map 0.857 0.923 No Hit 0.0% —
1304 KP13_02223 Protein finK fimK AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
No map 0.857 0.385 No Hit 0.0% —
1305 KP13_01301 tRNA-(ms[2]io[6]A)-hydroxylase AlphaFold DB model + ColabFold model –
GO:0045301Catalysis of the reaction: 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + acceptor-H2 + O2 = N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA + acceptor + H2O. GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
No map 0.857 0.974 No Hit 0.0% —
1306 KP13_01035 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.857 0.293 No Hit 0.0% —
1307 KP13_31932 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.856 No Hit 0.0% —
1308 KP13_31835 HTH-type transcriptional regulator AscG AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.856 0.783 No Hit 0.0% —
1309 KP13_00403 Outer membrane protein assembly factor AlphaFold DB model + ColabFold model –
GO:0071709The aggregation, arrangement and bonding together of a set of components to form a membrane. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +25 total
No map 0.856 0.771 No Hit 0.0% —
1310 KP13_05374 putative intracellular septation protein ispZ AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.855 0.972 No Hit 0.0% —
1311 KP13_03636 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +36 total
No map 0.855 0.867 Hit 24.4% 1.32e-08
1312 KP13_03367 D-ribose-binding protein AlphaFold DB model + ColabFold model –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.855 0.66 No Hit 0.0% —
1313 KP13_02234 Putative nickel/cobalt efflux system AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0035444The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. +47 total
No map 0.855 0.996 No Hit 0.0% —
1314 KP13_01320 Protein iolH ioH AlphaFold DB model + ColabFold model – – No map 0.855 0.379 No Hit 0.0% —
1315 KP13_01103 Argininosuccinate synthase argG AlphaFold DB model + ColabFold model
6.3.4.5
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004055Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +47 total
No map 0.855 0.554 Hit 29.6% 3.31e-18
1316 KP13_00289 Cellulose synthase operon protein C AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0030244The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
No map 0.855 0.553 Hit 42.6% 3.90e-06
1317 KP13_05499 3-oxoacyl-[acyl-carrier-protein] synthase 2 fabF AlphaFold DB model + ColabFold model
2.3.1.179
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +25 total
No map 0.854 0.799 Hit 48.1% 1.78e-10
1318 KP13_02186 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.854 No Hit 0.0% —
1319 KP13_01571 putative Nudix hydrolase nudL nudL AlphaFold DB model + ColabFold model
3.6.1.-
GO:0030145Binding to a manganese ion (Mn). GO:0010945Catalysis of the reaction: an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+. This reaction can also use coenzyme A as a substrate. GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. +25 total
No map 0.854 0.455 Hit 41.8% 2.03e-12
1320 KP13_05213 putative oxidoreductase, Fe-S subunit AlphaFold DB model + ColabFold model –
GO:0016788Catalysis of the hydrolysis of any ester bond.
No map 0.853 0.18 No Hit 0.0% —
1321 KP13_05116 Oligopeptide ABC transport system oligopeptide-binding component AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
No map 0.853 0.602 No Hit 0.0% —
1322 KP13_05099 putative crestininase AlphaFold DB model + ColabFold model –
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0046872Binding to a metal ion. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
No map 0.853 0.673 No Hit 0.0% —
1323 KP13_03445 putative transcriptional regulator, GntR family/aminotransferase, classes I and II AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +47 total
No map 0.853 0.557 Hit 27.0% 1.18e-15
1324 KP13_01112 RNA-binding protein AlphaFold DB model + ColabFold model –
GO:0003723Binding to an RNA molecule or a portion thereof.
No map N/A 0.853 No Hit 0.0% —
1325 KP13_01043 3-ketoacyl-CoA thiolase fadI AlphaFold DB model + ColabFold model
2.3.1.16
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
No map 0.853 0.76 Hit 47.8% 7.17e-59
Page of 234 · 5842 total proteins