Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1251 KP13_04911 PTS system glucose-specific EIICB component ptsG AlphaFold DB model + ColabFold model
2.7.1.199
GO:1904659The process in which D-glucose is transported across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005355OBSOLETE. Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. +69 total
No map 0.865 0.928 No Hit 0.0% —
1252 KP13_04489 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.865 0.361 No Hit 0.0% —
1253 KP13_04072 hypothetical protein Experimental + ColabFold model –
GO:0046872Binding to a metal ion.
No map N/A 0.865 No Hit 0.0% —
1254 KP13_03710 Sensor kinase cusS cusS AlphaFold DB model + ColabFold model
2.7.13.3
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0004673Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. +69 total
No map 0.865 0.869 No Hit 0.0% —
1255 KP13_03152 Signal transduction histidine-protein kinase baeS baeS AlphaFold DB model + ColabFold model
2.7.13.3
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
No map 0.865 0.371 No Hit 0.0% —
1256 KP13_01793 Lysine decarboxylase, constitutive ldcC AlphaFold DB model + ColabFold model
4.1.1.18
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. +69 total
No map 0.865 0.248 No Hit 0.0% —
1257 KP13_32221 D-aminoacylase dan Experimental + ColabFold model –
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
No map 0.864 0.494 No Hit 0.0% —
1258 KP13_03352 Anaerobic C4-dicarboxylate transporter dcuC dcuC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015740The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. GO:0015556Enables the transfer of C4-dicarboxylate from one side of a membrane to the other. +14 total
No map 0.864 0.889 No Hit 0.0% —
1259 KP13_01747 Succinate-semialdehyde dehydrogenase [NADP+] AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0004030Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
No map 0.864 0.448 Hit 41.6% 8.47e-14
1260 KP13_01581 Ribosomal RNA large subunit methyltransferase A rlmA ColabFold model –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
No map 0.864 0.852 No Hit 0.0% —
1261 KP13_00050 DNA replication and repair protein recF recF AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0003697Binding to single-stranded DNA. +58 total
No map 0.864 0.812 No Hit 0.0% —
1262 KP13_31832 Sucrose-6-phosphate hydrolase cscA AlphaFold DB model + ColabFold model
3.2.1.26
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +25 total
No map 0.863 0.304 No Hit 0.0% —
1263 KP13_03908 Glucose-1-phosphatase agp AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0050308Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.
No map 0.863 0.17 No Hit 0.0% —
1264 KP13_03862 Ribosomal RNA large subunit methyltransferase E rlmL AlphaFold DB model + ColabFold model –
GO:0008990Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
No map 0.863 0.273 No Hit 0.0% —
1265 KP13_02285 Prolipoprotein diacylglyceryl transferase lgt AlphaFold DB model + ColabFold model
2.5.1.145
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042158The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. GO:0008961Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein.
No map 0.863 0.912 No Hit 0.0% —
1266 KP13_01060 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.863 0.719 No Hit 0.0% —
1267 KP13_32192 RmlC-type domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.862 0.584 No Hit 0.0% —
1268 KP13_31941 Lipid II flippase FtsW ftsW AlphaFold DB model + ColabFold model
2.4.99.28
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +710 total
No map 0.862 0.996 No Hit 0.0% —
1269 KP13_20969 GtrA family protein AlphaFold DB model + ColabFold model –
GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.862 0.563 No Hit 0.0% —
1270 KP13_00199 lipopolysaccharide core biosynthesis protein RfaZ rfaZ AlphaFold DB model + ColabFold model – – No map 0.862 0.478 No Hit 0.0% —
1271 KP13_05224 Serine/threonine-protein kinase HipA hipA AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
No map 0.861 0.939 No Hit 0.0% —
1272 KP13_04884 2-keto-3-deoxygluconate permease 1 kdgT1 AlphaFold DB model + ColabFold model –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015649Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in). +14 total
No map 0.861 0.946 No Hit 0.0% —
1273 KP13_04544 Inorganic pyrophosphatase AlphaFold DB model + ColabFold model
3.6.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006796The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. GO:0000287Binding to a magnesium (Mg) ion. +14 total
No map 0.861 0.633 Hit 35.3% 5.61e-10
1274 KP13_02983 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.861 0.36 No Hit 0.0% —
1275 KP13_02903 putative S-adenosyl-L-methionine dependent methyltransferase AlphaFold DB model + ColabFold model –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.861 0.569 No Hit 0.0% —
Page of 234 · 5842 total proteins