Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1276 KP13_01742 Fatty acid oxidation complex subunit alpha multifunctional enzyme fadB AlphaFold DB model + ColabFold model –
GO:0004165Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0004300Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O. +1114 total
No map 0.861 0.91 Hit 42.7% 6.90e-25
1277 KP13_01437 putative mercuric resistance protein merE AlphaFold DB model + ColabFold model –
GO:0015097Enables the transfer of mercury (Hg2+) ions from one side of a membrane to the other. GO:0015694The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map N/A 0.861 No Hit 0.0% —
1278 KP13_00201 ADP-heptose--LPS heptosyltransferase 2 rfaF AlphaFold DB model + ColabFold model
2.4.99.24
GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.861 0.05 No Hit 0.0% —
1279 KP13_32060 DNA-binding plasmid partition protein KorB AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.860 0.11 No Hit 0.0% —
1280 KP13_05476 Lambda repressor-like, DNA-binding domain-containing protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
No map 0.860 0.847 No Hit 0.0% —
1281 KP13_04467 Gamma-aminobutyraldehyde dehydrogenase prr AlphaFold DB model + ColabFold model –
GO:0019145Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+. GO:0009447The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +25 total
No map 0.860 0.858 Hit 54.4% 3.74e-11
1282 KP13_02882 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.860 0.937 No Hit 0.0% —
1283 KP13_01375 Uroporphyrinogen decarboxylase hemE AlphaFold DB model + ColabFold model
4.1.1.37
GO:0004853Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. GO:0006779The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.860 0.095 Hit 70.2% 6.51e-21
1284 KP13_01082 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.860 0.855 No Hit 0.0% —
1285 KP13_05264 L-lactate dehydrogenase 2 ldh2 AlphaFold DB model + ColabFold model
1.1.1.27
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
No map 0.859 0.568 Hit 34.4% 2.64e-36
1286 KP13_04667 putative H+/gluconate symporter AlphaFold DB model + ColabFold model – – No map 0.859 0.883 No Hit 0.0% —
1287 KP13_04434 Cytochrome b561 cybB AlphaFold DB model + ColabFold model –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022904A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. +36 total
No map 0.859 0.99 No Hit 0.0% —
1288 KP13_03861 2Fe-2S ferredoxin-type domain-containing protein AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0030151Binding to a molybdenum ion (Mo). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
No map 0.859 0.417 Hit 45.2% 1.36e-19
1289 KP13_01737 Deoxyribonuclease tatD tatD AlphaFold DB model + ColabFold model
3.1.11.- 3.1.13.-
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No map 0.859 0.007 Hit 36.4% 3.42e-14
1290 KP13_01208 Beta-xylosidase xynB AlphaFold DB model + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond.
No map 0.859 0.622 No Hit 0.0% —
1291 KP13_01005 putative Nudix hydrolase AlphaFold DB model + ColabFold model –
GO:0016817Catalysis of the hydrolysis of any acid anhydride. GO:0046872Binding to a metal ion.
No map 0.859 0.071 No Hit 0.0% —
1292 KP13_00193 putative glycosyltransferase in waa region AlphaFold DB model + ColabFold model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
No map 0.859 0.225 No Hit 0.0% —
1293 KP13_00051 DNA gyrase subunit B gyrB AlphaFold DB model + ColabFold model
5.6.2.2
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. +58 total
No map 0.859 0.793 Hit 26.4% 1.62e-30
1294 KP13_31922 EvpB family type VI secretion protein AlphaFold DB model + ColabFold model – – No map 0.858 0.217 No Hit 0.0% —
1295 KP13_31528 Threonyl-tRNA synthetase thrS AlphaFold DB model + ColabFold model –
GO:0004829Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
No map 0.858 0.204 Hit 40.9% 7.59e-88
1296 KP13_04932 Ribosomal-protein-alanine acetyltransferase rimJ AlphaFold DB model + ColabFold model
2.3.1.267
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008999Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-alanyl-[protein].
No map 0.858 0.552 No Hit 0.0% —
1297 KP13_04313 putative mscS family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. +14 total
No map 0.858 0.841 No Hit 0.0% —
1298 KP13_02856 putative aldolase LsrF lsrF AlphaFold DB model + ColabFold model –
GO:0004332Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
No map 0.858 0.116 No Hit 0.0% —
1299 KP13_02543 Hemin transport protein HmuS hmuS AlphaFold DB model + ColabFold model –
GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.858 0.367 No Hit 0.0% —
1300 KP13_11760 3'(2'),5'-bisphosphate nucleotidase cysQ cysQ AlphaFold DB model + ColabFold model
3.1.3.7
GO:0046854The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0006790The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. +47 total
No map 0.857 0.559 Hit 30.5% 3.30e-11
Page of 234 · 5842 total proteins