Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1351 KP13_05543 putative lactonase AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
No map 0.848 0.667 No Hit 0.0% —
1352 KP13_05372 putative ferredoxin-like protein AlphaFold DB model + ColabFold model – – No map 0.848 0.48 No Hit 0.0% —
1353 KP13_04890 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.848 No Hit 0.0% —
1354 KP13_04799 putative MobB mobilization protein AlphaFold DB model + ColabFold model – – No map 0.848 0.642 No Hit 0.0% —
1355 KP13_04514 HTH-type transcriptional regulator betI AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.848 0.997 No Hit 0.0% —
1356 KP13_04369 Transaminase mtnE mtnE AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
No map 0.848 0.921 Hit 24.5% 6.64e-11
1357 KP13_03572 Transcriptional activator cadC cadC AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +14 total
No map 0.848 0.803 No Hit 0.0% —
1358 KP13_01908 Phospho-N-acetylmuramoyl-pentapeptide- transferase mraY AlphaFold DB model + ColabFold model
2.7.8.13
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008963Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP. GO:0016780Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). +710 total
No map 0.848 0.685 No Hit 0.0% —
1359 KP13_01197 hypothetical protein ColabFold model – – No map 0.848 0.671 No Hit 0.0% —
1360 KP13_04548 putative glycosyltransferase AlphaFold DB model + ColabFold model – – No map 0.847 0.909 No Hit 0.0% —
1361 KP13_05274 inner membrane protein marC marC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.846 0.782 No Hit 0.0% —
1362 KP13_04109 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +36 total
No map 0.846 0.562 Hit 23.6% 7.62e-10
1363 KP13_03754 putative manganese transport protein mntH mntH AlphaFold DB model + ColabFold model –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0046873Enables the transfer of metal ions from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +69 total
No map 0.846 0.985 Hit 46.4% 4.91e-17
1364 KP13_01883 Aromatic amino acid transport protein aroP aroP AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.846 0.73 Hit 25.1% 8.27e-12
1365 KP13_05462 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.845 0.702 No Hit 0.0% —
1366 KP13_04647 putative methylcobalamin:homocysteine methyltransferase metE AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0003871Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +14 total
No map 0.845 0.866 No Hit 0.0% —
1367 KP13_03810 hypothetical protein ColabFold model – – No map N/A 0.845 No Hit 0.0% —
1368 KP13_03514 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.845 0.983 No Hit 0.0% —
1369 KP13_00227 L-seryl-tRNA(Sec) selenium transferase selA AlphaFold DB model + ColabFold model
2.9.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004125Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
No map 0.845 0.321 No Hit 0.0% —
1370 KP13_32383 sulfate permease AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.844 0.946 Hit 26.8% 6.92e-06
1371 KP13_03154 putative protease AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +14 total
No map 0.844 0.604 No Hit 0.0% —
1372 KP13_02372 LOG family protein AlphaFold DB model + ColabFold model
3.2.2.10 3.2.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008714Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine. GO:0047405Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine.
No map 0.844 0.896 No Hit 0.0% —
1373 KP13_01163 NAGC-like transcriptional regulator mlc AlphaFold DB model + ColabFold model – – No map 0.844 0.209 Hit 24.7% 2.59e-11
1374 KP13_04912 putative deoxyribonuclease AlphaFold DB model + ColabFold model –
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0004536Catalysis of the cleavage of ester linkages within deoxyribonucleic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.843 0.333 Hit 35.2% 1.68e-19
1375 KP13_02243 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
No map 0.843 0.208 No Hit 0.0% —
Page of 234 · 5842 total proteins