Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1501 KP13_00353 Acetate operon repressor iclR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.897 No Hit 0.0% —
1502 KP13_00355 Na/Pi co-transporter II-related protein AlphaFold + ColabFold –
GO:0005436Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0044341The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.
0.98 No Hit 0.0% —
1503 KP13_00356 Peptidase E pepE AlphaFold + ColabFold
3.4.13.21
GO:0016805Catalysis of the hydrolysis of a dipeptide. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +14 total
0.365 No Hit 0.0% —
1504 KP13_00357 Ribosomal large subunit pseudouridine synthase F rluF AlphaFold + ColabFold
5.4.99.-
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. +47 total
0.483 No Hit 0.0% —
1505 KP13_00358 hypothetical protein AlphaFold + ColabFold – – 0.213 No Hit 0.0% —
1506 KP13_00360 Lysine-sensitive aspartokinase 3 lysC AlphaFold + ColabFold
2.7.2.4
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0004072Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. +47 total
0.596 No Hit 0.0% —
1507 KP13_00361 hypothetical protein ColabFold – – 0.803 No Hit 0.0% —
1508 KP13_00363 LpxA-like domain-containing transferase AlphaFold + ColabFold – – 0.258 No Hit 0.0% —
1509 KP13_00366 putative branched-chain amino acid transport protein AlphaFold + ColabFold – – 0.982 No Hit 0.0% —
1510 KP13_00367 putative branched-chain amino acid transport protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1903785The directed movement of L-valine across a membrane.
0.717 No Hit 0.0% —
1511 KP13_00368 Serine dehydratase-like, alpha subunit domain-containing protein AlphaFold + ColabFold – – 0.505 No Hit 0.0% —
1512 KP13_00369 protein psiE psiE AlphaFold + ColabFold –
GO:0016036Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.897 No Hit 0.0% —
1513 KP13_00370 Maltose transport system permease protein malG malG AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.878 No Hit 0.0% —
1514 KP13_00371 Maltose transport system permease protein malF malF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990060Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. +25 total
0.51 No Hit 0.0% —
1515 KP13_00372 Maltose-binding periplasmic protein malE AlphaFold + ColabFold –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0015144Enables the transfer of carbohydrate from one side of a membrane to the other. +58 total
0.641 No Hit 0.0% —
1516 KP13_00374 Maltoporin 2 lamB2 AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0042956The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane. GO:0034219The process in which a carbohydrate is transported across a membrane. +710 total
0.718 No Hit 0.0% —
1517 KP13_00375 Maltose operon periplasmic protein malM AlphaFold + ColabFold –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.431 No Hit 0.0% —
1518 KP13_00376 Chorismate--pyruvate lyase ubiC AlphaFold + ColabFold
4.1.3.40
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008813Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. +25 total
0.748 No Hit 0.0% —
1519 KP13_00379 Diacylglycerol kinase dgkA AlphaFold + ColabFold
2.7.1.107
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004143Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +69 total
0.837 No Hit 0.0% —
1520 KP13_00380 LexA repressor lexA AlphaFold + ColabFold
3.4.21.88
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009432An error-prone process for repairing damaged microbial DNA. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +58 total
0.237 No Hit 0.0% —
1521 KP13_00381 DNA-damage-inducible protein F dinF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +25 total
0.788 No Hit 0.0% —
1522 KP13_00382 General stress response CsbD-like protein AlphaFold + ColabFold – – 0.639 No Hit 0.0% —
1523 KP13_00384 hypothetical protein AlphaFold + ColabFold – – 0.368 No Hit 0.0% —
1524 KP13_00387 Phage shock protein G AlphaFold + ColabFold – – 0.5 No Hit 0.0% —
1525 KP13_00389 Replicative DNA helicase dnaB AlphaFold + ColabFold
5.6.2.3
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +710 total
0.535 No Hit 0.0% —
Page of 234 · 5842 total proteins