Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1751 KP13_01670 hypothetical protein AlphaFold + ColabFold – – 0.733 No Hit 0.0% —
1752 KP13_00963 Anaerobic glycerol-3-phosphate dehydrogenase subunit B glpB AlphaFold + ColabFold
1.1.5.3
GO:0004368Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. GO:0009331An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions. GO:0019563The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
0.733 No Hit 0.0% —
1753 KP13_00812 Signal peptidase I lepB AlphaFold + ColabFold
3.4.21.89
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006465OBSOLETE. The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +47 total
0.733 No Hit 0.0% —
1754 KP13_00602 HTH-type transcriptional regulator rafR rafR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.733 No Hit 0.0% —
1755 KP13_05242 putative 2-nitropropane dioxygenase AlphaFold + ColabFold –
GO:0018580Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite. GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +14 total
0.732 No Hit 0.0% —
1756 KP13_04138 putative pyruvate/Phosphoenolpyruvate kinase AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.732 No Hit 0.0% —
1757 KP13_02909 GABA permease gabP AlphaFold + ColabFold –
GO:0015812The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.732 Hit 24.5% 1.82e-06
1758 KP13_32091 ATPases of the AAA+ class AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.731 Hit 36.9% 4.22e-06
1759 KP13_03743 Guanine deaminase guaD AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +25 total
0.731 Hit 26.2% 1.59e-09
1760 KP13_03294 hypothetical protein AlphaFold + ColabFold – – 0.731 No Hit 0.0% —
1761 KP13_03179 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.731 No Hit 0.0% —
1762 KP13_02946 hypothetical protein ColabFold – – 0.731 No Hit 0.0% —
1763 KP13_01880 Pyruvate dehydrogenase E1 component aceE AlphaFold + ColabFold
1.2.4.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.731 Hit 29.8% 7.35e-09
1764 KP13_00444 Ribose transport system permease protein rbsC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.731 No Hit 0.0% —
1765 KP13_00113 putative 6-phosphogluconate dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
0.731 No Hit 0.0% —
1766 KP13_03920 HTH-type transcriptional regulator rutR rutR AlphaFold + ColabFold –
GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.73 No Hit 0.0% —
1767 KP13_03709 hypothetical protein Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.73 No Hit 0.0% —
1768 KP13_03182 Protein mrp mrp AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0140663Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
0.73 Hit 48.8% 5.08e-08
1769 KP13_01883 Aromatic amino acid transport protein aroP aroP AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.73 Hit 25.1% 8.27e-12
1770 KP13_32005 Cyd operon protein ColabFold – – 0.729 No Hit 0.0% —
1771 KP13_05112 Oligopeptide ABC transport system ATP-binding component AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.729 Hit 32.6% 2.55e-16
1772 KP13_04608 Acetaldehyde dehydrogenase mhpF AlphaFold + ColabFold
1.2.1.10
GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +25 total
0.729 No Hit 0.0% —
1773 KP13_03277 2-oxoglutarate dehydrogenase E1 component sucA AlphaFold + ColabFold
1.2.4.2
GO:0016624Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. GO:0004591Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. +36 total
0.729 Hit 47.1% 1.94e-39
1774 KP13_02484 Endoribonuclease L-PSP family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
0.729 Hit 30.3% 2.63e-14
1775 KP13_01993 Bifunctional aspartokinase/homoserine dehydrogenase 1 thrA AlphaFold + ColabFold –
GO:0009067The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004412Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. +1013 total
0.729 No Hit 0.0% —
Page of 234 · 5842 total proteins