Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1776 KP13_05108 Major facilitator superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.765 0.886 No Hit 0.0% —
1777 KP13_02018 putative deoxyribonuclease AlphaFold DB model + ColabFold model –
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion.
No map 0.765 0.28 Hit 34.6% 6.47e-14
1778 KP13_01039 putative adenine-specific methylase AlphaFold DB model + ColabFold model
2.1.1.298
GO:0009007Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003676Binding to a nucleic acid. +710 total
No map 0.765 0.957 Hit 29.0% 3.21e-14
1779 KP13_32063 hypothetical protein ColabFold model – – No map N/A 0.764 No Hit 0.0% —
1780 KP13_21046 Uracil phosphoribosyltransferase upp Experimental + ColabFold model –
GO:0006223Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis. GO:0004845Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil.
No map 0.764 0.314 Hit 28.7% 2.62e-09
1781 KP13_06717 DnaJ domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.764 0.855 Hit 42.6% 1.73e-06
1782 KP13_01710 Diaminopimelate epimerase dapF AlphaFold DB model + ColabFold model
5.1.1.7
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0008837Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate. +14 total
No map 0.764 0.203 No Hit 0.0% —
1783 KP13_01626 putative isochorismatase family protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.764 0.723 No Hit 0.0% —
1784 KP13_04235 Low specificity L-threonine aldolase ltaE AlphaFold DB model + ColabFold model –
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
No map 0.763 0.453 No Hit 0.0% —
1785 KP13_04201 Phosphoserine aminotransferase serC Experimental + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006564The chemical reactions and pathways resulting in the formation of L-serine. GO:0004648Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
No map 0.763 0.699 Hit 47.8% 1.14e-118
1786 KP13_01993 Bifunctional aspartokinase/homoserine dehydrogenase 1 thrA AlphaFold DB model + ColabFold model –
GO:0009067The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004412Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. +1013 total
No map 0.763 0.729 No Hit 0.0% —
1787 KP13_00578 ATP-dependent hsl protease ATP-binding subunit hslU hslU AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009376A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +36 total
No map 0.763 0.618 Hit 29.4% 1.82e-17
1788 KP13_00057 2-dehydro-3-deoxy-6-phosphogalactonate aldolase dgoA AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
No map 0.763 0.411 No Hit 0.0% —
1789 KP13_05448 Phage shock protein A pspA AlphaFold DB model + ColabFold model – – No map N/A 0.762 No Hit 0.0% —
1790 KP13_04498 putative GST-like protein AlphaFold DB model + ColabFold model – – No map 0.762 0.014 No Hit 0.0% —
1791 KP13_04177 hypothetical protein ColabFold model – – No map 0.762 0.296 No Hit 0.0% —
1792 KP13_00841 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.762 0.707 No Hit 0.0% —
1793 KP13_00631 putative acyltransferase ColabFold model –
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
No map 0.762 0.973 No Hit 0.0% —
1794 KP13_04926 Ribonuclease E rne AlphaFold DB model + ColabFold model
3.1.26.12
GO:0003676Binding to a nucleic acid. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. +1114 total
No map 0.761 0.832 No Hit 0.0% —
1795 KP13_05503 Aspartate-semialdehyde dehydrogenase AlphaFold DB model + ColabFold model
1.2.1.11
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0009097OBSOLETE. The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. +912 total
No map 0.760 0.838 No Hit 0.0% —
1796 KP13_04939 Biofilm regulator bssS bssS AlphaFold DB model + ColabFold model – – No map N/A 0.76 No Hit 0.0% —
1797 KP13_04268 Phosphatase AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.760 0.622 No Hit 0.0% —
1798 KP13_02001 Protein creA creA AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map N/A 0.76 No Hit 0.0% —
1799 KP13_00258 HTH-type transcriptional regulator kdgR kdgR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.760 0.737 No Hit 0.0% —
1800 KP13_04889 Sorbitol operon regulator sorC AlphaFold DB model + ColabFold model –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0006352The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
No map 0.759 0.658 No Hit 0.0% —
Page of 234 · 5842 total proteins