Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1801 KP13_00856 putative lipoprotein AlphaFold DB model + ColabFold model –
GO:0004866Binds to and stops, prevents or reduces the activity of an endopeptidase. GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
No map 0.759 0.307 Hit 26.1% 3.54e-06
1802 KP13_00203 putative 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase AlphaFold DB model + ColabFold model
2.3.1.29
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +69 total
No map 0.759 0.193 Hit 55.4% 1.78e-149
1803 KP13_31786 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.758 No Hit 0.0% —
1804 KP13_05381 Inner membrane protein AlphaFold DB model + ColabFold model – – No map 0.758 0.988 No Hit 0.0% —
1805 KP13_05269 putative dihydrodipicolinate synthase AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+. GO:0044281The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
No map 0.758 0.283 Hit 28.8% 3.78e-18
1806 KP13_03190 Putative osmoprotectant uptake system permease protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.758 0.987 No Hit 0.0% —
1807 KP13_01984 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015360Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in). +14 total
No map 0.758 0.46 No Hit 0.0% —
1808 KP13_00367 putative branched-chain amino acid transport protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1903785The directed movement of L-valine across a membrane.
No map 0.758 0.717 No Hit 0.0% —
1809 KP13_04024 Peptidase S49 AlphaFold DB model + ColabFold model –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
No map 0.757 0.933 No Hit 0.0% —
1810 KP13_03867 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.757 No Hit 0.0% —
1811 KP13_03803 putative glycosyltransferase family 2 in cps region AlphaFold DB model + ColabFold model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
No map 0.757 0.012 No Hit 0.0% —
1812 KP13_01990 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.757 No Hit 0.0% —
1813 KP13_02375 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.756 No Hit 0.0% —
1814 KP13_02346 Cysteine sulfinate desulfinase csdA AlphaFold DB model + ColabFold model
2.8.1.7
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. +25 total
No map 0.756 0.279 Hit 30.1% 2.15e-07
1815 KP13_00301 GCN5-related N-acetyltransferase AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.756 0.478 No Hit 0.0% —
1816 KP13_32086 conjugal transfer traI-like protein AlphaFold DB model + ColabFold model – – No map 0.755 0.563 No Hit 0.0% —
1817 KP13_06695 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.755 No Hit 0.0% —
1818 KP13_05185 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.755 0.049 No Hit 0.0% —
1819 KP13_05050 hypothetical protein ColabFold model – – No map N/A 0.755 No Hit 0.0% —
1820 KP13_04416 putative endonuclease 4 nfo AlphaFold DB model + ColabFold model
3.1.21.2
GO:0008270Binding to a zinc ion (Zn). GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
No map 0.755 0.69 No Hit 0.0% —
1821 KP13_02909 GABA permease gabP AlphaFold DB model + ColabFold model –
GO:0015812The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
No map 0.755 0.732 Hit 24.5% 1.82e-06
1822 KP13_02758 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
No map 0.755 0.21 No Hit 0.0% —
1823 KP13_00941 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.755 0.941 No Hit 0.0% —
1824 KP13_32196 HTH-type transcriptional regulator MetR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.754 0.3 No Hit 0.0% —
1825 KP13_05385 polysaccharide deacetylase domain-containing protein Experimental + ColabFold model –
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0000272The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.754 0.809 Hit 29.0% 1.68e-21
Page of 234 · 5842 total proteins