Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 / 5842 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1726 KP13_22167 Ribonucleoside-diphosphate reductase 2 subunit alpha nrdE AlphaFold DB model + ColabFold model
1.17.4.1
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0004748Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. +25 total
No map 0.777 0.238 Hit 34.0% 1.28e-10
1727 KP13_04960 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.777 0.547 No Hit 0.0% —
1728 KP13_04794 hypothetical protein ColabFold model – – No map 0.777 0.177 No Hit 0.0% —
1729 KP13_02710 putative deoxythimodone diphosphates-4-dehydrorhamnose 3,5-epimerase AlphaFold DB model + ColabFold model – – No map 0.777 0.777 No Hit 0.0% —
1730 KP13_01951 Sensor histidine kinase CitA citA AlphaFold DB model + ColabFold model –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +14 total
No map 0.777 0.933 No Hit 0.0% —
1731 KP13_01921 2-isopropylmalate synthase leuA AlphaFold DB model + ColabFold model
2.3.3.13
GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0003852Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+. GO:0009098The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid. +58 total
No map 0.777 0.206 Hit 25.0% 5.45e-07
1732 KP13_01882 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.777 No Hit 0.0% —
1733 KP13_01548 Cell volume regulation protein A cvrA AlphaFold DB model + ColabFold model –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). GO:1902600The directed movement of a proton across a membrane. +811 total
No map 0.777 0.654 No Hit 0.0% —
1734 KP13_05139 HTH-type transcriptional repressor purR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
No map 0.776 0.774 No Hit 0.0% —
1735 KP13_05047 Fumarate hydratase class I, anaerobic fumB AlphaFold DB model + ColabFold model
4.2.1.2
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. +58 total
No map 0.776 0.481 No Hit 0.0% —
1736 KP13_00779 Ribosomal RNA small subunit methyltransferase B rsmB AlphaFold DB model + ColabFold model
2.1.1.176
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
No map 0.776 0.079 Hit 34.5% 2.37e-23
1737 KP13_05191 D-allulose-6-phosphate 3-epimerase AlphaFold DB model + ColabFold model
5.1.3.-
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0034700Catalysis of the reaction: D-allulose 6-phosphate = keto-D-fructose 6-phosphate. GO:0046872Binding to a metal ion. +69 total
No map 0.775 0.512 Hit 33.7% 2.31e-27
1738 KP13_03881 Ribosomal RNA large subunit methyltransferase I rlmI AlphaFold DB model + ColabFold model
2.1.1.191
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +25 total
No map 0.775 0.372 No Hit 0.0% —
1739 KP13_02365 putative lipoprotein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.775 0.242 No Hit 0.0% —
1740 KP13_01644 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.775 No Hit 0.0% —
1741 KP13_03725 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.773 0.665 No Hit 0.0% —
1742 KP13_01692 UDP-N-acetyl-D-mannosamine dehydrogenase wecC AlphaFold DB model + ColabFold model
1.1.1.336
GO:0089714Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+. GO:0016628Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +36 total
No map 0.773 0.618 Hit 31.8% 8.65e-06
1743 KP13_07457 RCK domain-containing protein AlphaFold DB model + ColabFold model –
GO:0006813The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008324Enables the transfer of cation from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.772 0.817 No Hit 0.0% —
1744 KP13_03401 Ferrienterobactin-binding periplasmic protein fepB AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.772 0.71 No Hit 0.0% —
1745 KP13_03079 F-type conjugal transfer protein TraC ColabFold model – – No map 0.772 0.612 No Hit 0.0% —
1746 KP13_00629 DNA polymerase I polA AlphaFold DB model + ColabFold model –
GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003676Binding to a nucleic acid. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +58 total
No map 0.772 0.408 Hit 36.4% 3.63e-43
1747 KP13_00278 Cellulose synthase operon protein C bcsC AlphaFold DB model + ColabFold model –
GO:0030244The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515Binding to a protein. +25 total
No map 0.772 0.793 No Hit 0.0% —
1748 KP13_04702 UTP--glucose-1-phosphate uridylyltransferase galU AlphaFold DB model + ColabFold model
2.7.7.9
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0006011The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate. GO:0003983Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. +14 total
No map 0.771 0.28 Hit 26.4% 2.91e-06
1749 KP13_04398 putative ABC transporter ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.771 0.085 Hit 40.3% 1.11e-06
1750 KP13_03886 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043066Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.771 0.704 Hit 30.3% 3.14e-06
Page of 234 · 5842 total proteins