Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
201 KP13_00334 putative integral membrane protein AlphaFold + ColabFold –
GO:1990397OBSOLETE. Any process which produces queuosine from derivatives of it, without de novo synthesis.
0.987 No Hit 0.0% —
202 KP13_00335 Sulfurtransferase tusA tusA AlphaFold + ColabFold –
GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.25 No Hit 0.0% —
203 KP13_00337 TMEM86 family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.988 No Hit 0.0% —
204 KP13_00338 hypothetical protein AlphaFold + ColabFold – – 0.323 No Hit 0.0% —
205 KP13_00339 hypothetical protein AlphaFold + ColabFold – – 0.472 No Hit 0.0% —
206 KP13_00340 Ribosomal RNA small subunit methyltransferase D rsmD AlphaFold + ColabFold
2.1.1.171
GO:0003676Binding to a nucleic acid. GO:0032259The process in which a methyl group is covalently attached to a molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +25 total
0.395 No Hit 0.0% —
207 KP13_00343 Cell division protein ftsX ftsX AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. +14 total
0.641 No Hit 0.0% —
208 KP13_00348 putative N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.774 No Hit 0.0% —
209 KP13_00350 Malate synthase A aceB AlphaFold + ColabFold –
GO:0004474Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006097A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
0.522 No Hit 0.0% —
210 KP13_00351 Isocitrate lyase aceA AlphaFold + ColabFold
4.1.3.1
GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004451Catalysis of the reaction: isocitrate = glyoxylate + succinate. +36 total
0.795 No Hit 0.0% —
211 KP13_00352 Isocitrate dehydrogenase kinase/phosphatase aceK AlphaFold + ColabFold
2.7.11.5 3.1.3.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +710 total
0.95 No Hit 0.0% —
212 KP13_00353 Acetate operon repressor iclR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.897 No Hit 0.0% —
213 KP13_00355 Na/Pi co-transporter II-related protein AlphaFold + ColabFold –
GO:0005436Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0044341The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.
0.98 No Hit 0.0% —
214 KP13_00356 Peptidase E pepE AlphaFold + ColabFold
3.4.13.21
GO:0016805Catalysis of the hydrolysis of a dipeptide. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +14 total
0.365 No Hit 0.0% —
215 KP13_00357 Ribosomal large subunit pseudouridine synthase F rluF AlphaFold + ColabFold
5.4.99.-
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. +47 total
0.483 No Hit 0.0% —
216 KP13_00358 hypothetical protein AlphaFold + ColabFold – – 0.213 No Hit 0.0% —
217 KP13_00360 Lysine-sensitive aspartokinase 3 lysC AlphaFold + ColabFold
2.7.2.4
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0004072Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. +47 total
0.596 No Hit 0.0% —
218 KP13_00361 hypothetical protein ColabFold – – 0.803 No Hit 0.0% —
219 KP13_00363 LpxA-like domain-containing transferase AlphaFold + ColabFold – – 0.258 No Hit 0.0% —
220 KP13_00366 putative branched-chain amino acid transport protein AlphaFold + ColabFold – – 0.982 No Hit 0.0% —
221 KP13_00367 putative branched-chain amino acid transport protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1903785The directed movement of L-valine across a membrane.
0.717 No Hit 0.0% —
222 KP13_00368 Serine dehydratase-like, alpha subunit domain-containing protein AlphaFold + ColabFold – – 0.505 No Hit 0.0% —
223 KP13_00369 protein psiE psiE AlphaFold + ColabFold –
GO:0016036Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.897 No Hit 0.0% —
224 KP13_00370 Maltose transport system permease protein malG malG AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.878 No Hit 0.0% —
225 KP13_00371 Maltose transport system permease protein malF malF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990060Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. +25 total
0.51 No Hit 0.0% —
Page of 234 · 5842 total proteins