Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2351 KP13_02314 Diol dehydratase-reactivating factor alpha subunit ddrA AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion.
0.638 No Hit 0.0% —
2352 KP13_01988 putative transporter AlphaFold + ColabFold –
GO:0005283Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.638 No Hit 0.0% —
2353 KP13_01443 Mercuric resistance operon regulatory protein merR AlphaFold + ColabFold –
GO:0045340Binding to a mercury ion (Hg2+). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.638 No Hit 0.0% —
2354 KP13_00649 sn-glycerol-3-phosphate transport system permease protein ugpE ugpE AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.638 No Hit 0.0% —
2355 KP13_31558 Protein bax bax AlphaFold + ColabFold –
GO:0004040Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+.
0.637 No Hit 0.0% —
2356 KP13_04603 putative cysteine dioxygenase type I AlphaFold + ColabFold
1.13.11.-
GO:0016702Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. GO:0005506Binding to an iron (Fe) ion. GO:0008198Binding to a ferrous iron ion, Fe(II).
0.637 No Hit 0.0% —
2357 KP13_03102 hypothetical protein AlphaFold + ColabFold – – 0.637 No Hit 0.0% —
2358 KP13_01129 hypothetical protein AlphaFold + ColabFold
2.7.1.217
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.637 No Hit 0.0% —
2359 KP13_00919 hypothetical protein AlphaFold + ColabFold – – 0.637 No Hit 0.0% —
2360 KP13_00595 putative rhamnose ABC transporter, ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.637 Hit 40.4% 6.23e-11
2361 KP13_31985 hypothetical protein ColabFold – – 0.636 No Hit 0.0% —
2362 KP13_31509 L-2,4-diaminobutyrate decarboxylase ddc AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016830Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. +36 total
0.636 Hit 49.0% 1.76e-23
2363 KP13_05489 putative esterase AlphaFold + ColabFold
3.1.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.636 No Hit 0.0% —
2364 KP13_04549 NAD-dependent malic enzyme sfcA AlphaFold + ColabFold
1.1.1.38
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0004470Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. GO:0004471Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. +47 total
0.636 Hit 48.6% 9.06e-81
2365 KP13_04153 hypothetical protein AlphaFold + ColabFold – – 0.636 No Hit 0.0% —
2366 KP13_03168 Ribitol 2-dehydrogenase rbtD AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.636 Hit 51.1% 1.76e-06
2367 KP13_02806 Adenylate cyclase domain-containing protein AlphaFold + ColabFold –
GO:0050355Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate. GO:0046872Binding to a metal ion.
0.636 No Hit 0.0% —
2368 KP13_02453 hypothetical protein AlphaFold + ColabFold – – 0.636 No Hit 0.0% —
2369 KP13_02301 Propanediol utilization protein pduV pduV AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006576The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
0.636 No Hit 0.0% —
2370 KP13_04705 hypothetical protein AlphaFold + ColabFold – – 0.635 No Hit 0.0% —
2371 KP13_03444 putative transcriptional regulator, GntR family AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +36 total
0.635 Hit 23.9% 1.11e-21
2372 KP13_01719 ATP-dependent DNA helicase recQ recQ AlphaFold + ColabFold
5.6.2.4
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. +1518 total
0.635 Hit 55.1% 7.66e-13
2373 KP13_00857 Penicillin-binding protein 1C pbpC AlphaFold + ColabFold
2.4.99.28
GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0008955Catalysis of the reaction: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+. +36 total
0.635 No Hit 0.0% —
2374 KP13_31877 hypothetical protein Experimental + ColabFold – – 0.634 No Hit 0.0% —
2375 KP13_05488 AraC family transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.634 No Hit 0.0% —
Page of 234 · 5842 total proteins