Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2301 KP13_05017 DNA replication terminus site-binding protein tus AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006274The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.646 No Hit 0.0% —
2302 KP13_02054 Preprotein translocase subunit AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.646 No Hit 0.0% —
2303 KP13_01818 Deoxyguanosinetriphosphate triphosphohydrolase dgt AlphaFold + ColabFold
3.1.5.1
GO:0016793Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group. GO:0008832Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate. GO:0006203The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. +14 total
0.646 No Hit 0.0% —
2304 KP13_01476 Type VI secretion system-like protein AlphaFold + ColabFold – – 0.646 No Hit 0.0% —
2305 KP13_05338 GTP cyclohydrolase-2 ribA AlphaFold + ColabFold
3.5.4.25
GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). GO:0003935Catalysis of the reaction: GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H+ + 2 phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.645 No Hit 0.0% —
2306 KP13_04710 Respiratory nitrate reductase 1 delta chain narJ AlphaFold + ColabFold –
GO:0051131The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. GO:0051082Binding to an unfolded protein. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.645 No Hit 0.0% —
2307 KP13_02659 putative transmembrane protein AlphaFold + ColabFold – – 0.645 No Hit 0.0% —
2308 KP13_01663 Cystine-binding periplasmic protein fliY AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
0.645 Hit 35.7% 5.15e-06
2309 KP13_00862 Histidyl-tRNA synthetase hisS AlphaFold + ColabFold
6.1.1.21
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004821Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.645 Hit 25.3% 6.26e-11
2310 KP13_31959 diguanylate cyclase domain-containing protein AlphaFold + ColabFold –
GO:0005515Binding to a protein.
0.644 No Hit 0.0% —
2311 KP13_01483 hypothetical protein AlphaFold + ColabFold – – 0.644 No Hit 0.0% —
2312 KP13_01100 Translation initiation factor IF-2 infB AlphaFold + ColabFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. +36 total
0.644 Hit 41.5% 5.97e-126
2313 KP13_00087 hypothetical protein AlphaFold + ColabFold – – 0.644 No Hit 0.0% —
2314 KP13_00010 Low affinity potassium transport system protein kup kup AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071805A process in which a potassium ion is transported from one side of a membrane to the other. GO:0015079Enables the transfer of potassium ions (K+) from one side of a membrane to the other.
0.644 No Hit 0.0% —
2315 KP13_31939 Electron transport complex protein rnfC rnfC AlphaFold + ColabFold
7.-.-.-
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.643 No Hit 0.0% —
2316 KP13_05057 hypothetical protein ColabFold – – 0.643 No Hit 0.0% —
2317 KP13_04492 hypothetical protein AlphaFold + ColabFold
1.-.-.-
GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
0.643 No Hit 0.0% —
2318 KP13_02483 Sodium/solute symporter (SSS) family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.643 Hit 29.2% 4.50e-06
2319 KP13_01061 Type VI secretion system VgrG family protein AlphaFold + ColabFold – – 0.643 No Hit 0.0% —
2320 KP13_04799 putative MobB mobilization protein AlphaFold + ColabFold – – 0.642 No Hit 0.0% —
2321 KP13_04695 Oligopeptide transport system permease protein oppB oppB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.642 No Hit 0.0% —
2322 KP13_03806 putative tyrosine-protein kinase in cps region wzc AlphaFold + ColabFold
2.7.10.2 2.7.10.-
GO:0045226OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. +58 total
0.642 No Hit 0.0% —
2323 KP13_00960 Glycerophosphoryl diester phosphodiesterase glpQ AlphaFold + ColabFold
3.1.4.46
GO:0008081Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +25 total
0.642 Hit 32.6% 4.60e-07
2324 KP13_05330 putative amino acid ABC transporter, permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.641 No Hit 0.0% —
2325 KP13_03442 putative binding-protein-dependent transport system protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +25 total
0.641 No Hit 0.0% —
Page of 234 · 5842 total proteins