Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2401 KP13_01678 phage T7 DNA primase-helicase AlphaFold + ColabFold –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
No map 0.24 No Hit 0.0% —
2402 KP13_01679 hypothetical protein AlphaFold + ColabFold – – No map 0.592 No Hit 0.0% —
2403 KP13_01680 hypothetical protein ColabFold – – No map 0.368 No Hit 0.0% —
2404 KP13_01681 putative inner membrane protein AlphaFold + ColabFold – – No map 0.842 No Hit 0.0% —
2405 KP13_01683 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.496 No Hit 0.0% —
2406 KP13_01689 Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase wecA AlphaFold + ColabFold
2.7.8.33
GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0016780Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). GO:0030145Binding to a manganese ion (Mn). +1013 total
No map 0.433 No Hit 0.0% —
2407 KP13_01695 Lipopolysaccharide biosynthesis protein rffC rffC AlphaFold + ColabFold
2.3.1.210
GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.814 No Hit 0.0% —
2408 KP13_01696 Lipopolysaccharide biosynthesis protein rffA rffA Experimental + ColabFold –
GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019180Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-alpha-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate.
No map 0.997 No Hit 0.0% —
2409 KP13_01697 Protein wzxE wzxE AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria.
No map 0.928 No Hit 0.0% —
2410 KP13_01698 4-alpha-L-fucosyltransferase wecF AlphaFold + ColabFold
2.4.1.325
GO:0008417Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. GO:0036065OBSOLETE. The covalent attachment of a fucosyl group to an acceptor molecule. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. +25 total
No map 0.951 No Hit 0.0% —
2411 KP13_01699 Putative ECA polymerase wzyE AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.862 No Hit 0.0% —
2412 KP13_01700 putative UDP-N-acetyl-D-mannosaminuronic acid transferase wecG AlphaFold + ColabFold
2.4.1.180
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. +25 total
No map 0.308 No Hit 0.0% —
2413 KP13_01702 hypothetical protein AlphaFold + ColabFold – – No map 0.033 No Hit 0.0% —
2414 KP13_01703 Protein hemY hemY AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515Binding to a protein. GO:0042168The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. +25 total
No map 0.844 No Hit 0.0% —
2415 KP13_01704 Putative uroporphyrinogen-III C-methyltransferase hemX AlphaFold + ColabFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.448 No Hit 0.0% —
2416 KP13_01705 Uroporphyrinogen-III synthase hemD AlphaFold + ColabFold
4.2.1.75
GO:0006780The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0004852Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III. +14 total
No map 0.575 No Hit 0.0% —
2417 KP13_01708 Protein cyaY cyaY AlphaFold + ColabFold –
GO:0008199Binding to a ferric iron ion, Fe(III). GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.07 No Hit 0.0% —
2418 KP13_01710 Diaminopimelate epimerase dapF AlphaFold + ColabFold
5.1.1.7
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0008837Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate. +14 total
No map 0.203 No Hit 0.0% —
2419 KP13_01711 hypothetical protein AlphaFold + ColabFold – – No map 0.478 No Hit 0.0% —
2420 KP13_01712 Tyrosine recombinase xerC xerC AlphaFold + ColabFold –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +58 total
No map 0.444 No Hit 0.0% —
2421 KP13_01714 DNA helicase II uvrD AlphaFold + ColabFold
5.6.2.4
GO:0006268OBSOLETE. The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +1013 total
No map 0.038 No Hit 0.0% —
2422 KP13_01715 Magnesium transport protein corA corA AlphaFold + ColabFold –
GO:0015087Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other. GO:0015693The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015095Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. +710 total
No map 0.763 No Hit 0.0% —
2423 KP13_01716 Protein rarD rarD AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.894 No Hit 0.0% —
2424 KP13_01717 Thioesterase domain-containing protein AlphaFold + ColabFold
3.1.2.20
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
No map 0.195 No Hit 0.0% —
2425 KP13_01718 Phospholipase A1 bifunctional protein pldA AlphaFold + ColabFold
3.1.1.32 3.1.1.4
GO:0004620Catalysis of the hydrolysis of a glycerophospholipid. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. +58 total
No map 0.67 No Hit 0.0% —
Page of 234 · 5842 total proteins