Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2451 KP13_03334 DNA polymerase III subunit delta holA AlphaFold + ColabFold
2.7.7.7
GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +25 total
0.622 No Hit 0.0% —
2452 KP13_01208 Beta-xylosidase xynB AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond.
0.622 No Hit 0.0% —
2453 KP13_01087 putative N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.622 No Hit 0.0% —
2454 KP13_00238 D-xylose-binding periplasmic protein xylF AlphaFold + ColabFold –
GO:0048029Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0015753The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.622 No Hit 0.0% —
2455 KP13_31553 Peptidase M23 protein AlphaFold + ColabFold –
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.621 No Hit 0.0% —
2456 KP13_05370 PKHD-type hydroxylase AlphaFold + ColabFold –
GO:0005506Binding to an iron (Fe) ion. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0031418Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. +14 total
0.621 No Hit 0.0% —
2457 KP13_02986 L(+)-tartrate dehydratase subunit beta ttdB AlphaFold + ColabFold
4.2.1.32
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0008730Catalysis of the reaction: L-tartrate = H2O + oxaloacetate.
0.621 No Hit 0.0% —
2458 KP13_32114 hypothetical protein ColabFold – – 0.62 No Hit 0.0% —
2459 KP13_04748 hypothetical protein AlphaFold + ColabFold – – 0.62 No Hit 0.0% —
2460 KP13_04597 ABC-type transport system, permease component AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.62 No Hit 0.0% —
2461 KP13_04273 hypothetical protein ColabFold – – 0.62 No Hit 0.0% —
2462 KP13_02507 putative GTP-binding protein AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.62 Hit 48.6% 1.08e-13
2463 KP13_02378 exonuclease IX AlphaFold + ColabFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +14 total
0.62 Hit 34.7% 4.85e-14
2464 KP13_01315 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
0.62 No Hit 0.0% —
2465 KP13_32001 hypothetical protein ColabFold – – 0.619 No Hit 0.0% —
2466 KP13_31578 EAL domain-containing protein AlphaFold + ColabFold –
GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
0.619 No Hit 0.0% —
2467 KP13_04442 Protocatechuate 3,4-dioxygenase beta chain AlphaFold + ColabFold –
GO:0016702Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. GO:0018578Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate. GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. +47 total
0.619 No Hit 0.0% —
2468 KP13_03612 Fosmidomycin resistance protein fsr AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.619 No Hit 0.0% —
2469 KP13_01950 Citrate/malate transporter cimH AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015711The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. GO:0008514OBSOLETE. Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. +36 total
0.619 No Hit 0.0% —
2470 KP13_00974 o-succinylbenzoate synthase menC AlphaFold + ColabFold
4.2.1.113
GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.619 No Hit 0.0% —
2471 KP13_00622 Glutamine synthetase glnA AlphaFold + ColabFold
6.3.1.2
GO:0004356Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. +69 total
0.619 Hit 27.5% 1.80e-12
2472 KP13_31822 LysR family regulatory protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.618 No Hit 0.0% —
2473 KP13_04523 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units.
0.618 Hit 36.1% 3.73e-13
2474 KP13_02343 Membrane-bound lytic murein transglycosylase A mltA AlphaFold + ColabFold
4.2.2.n1
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0009254The continual breakdown and regeneration of peptidoglycan required to maintain the bacterial cell wall. Peptidoglycans consist of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. +47 total
0.618 No Hit 0.0% —
2475 KP13_01692 UDP-N-acetyl-D-mannosamine dehydrogenase wecC AlphaFold + ColabFold
1.1.1.336
GO:0089714Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+. GO:0016628Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +36 total
0.618 Hit 31.8% 8.65e-06
Page of 234 · 5842 total proteins