Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2501 KP13_01295 Fructosamine kinase frlD frlD AlphaFold + ColabFold – – 0.614 No Hit 0.0% —
2502 KP13_32139 hypothetical protein ColabFold – – 0.613 No Hit 0.0% —
2503 KP13_32134 ATP-dependent Clp protease ATP-binding subunit ClpX clpX AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0008270Binding to a zinc ion (Zn). GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +811 total
0.613 Hit 62.2% 3.12e-07
2504 KP13_04511 Respiratory nitrate reductase 2 beta chain narY AlphaFold + ColabFold
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0042126The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. GO:0008940Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. +811 total
0.613 No Hit 0.0% —
2505 KP13_04141 hypothetical protein AlphaFold + ColabFold – – 0.613 No Hit 0.0% —
2506 KP13_01639 Trehalose-phosphate phosphatase otsB AlphaFold + ColabFold
3.1.3.12
GO:0004805Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005992The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose. +14 total
0.613 No Hit 0.0% —
2507 KP13_00402 hypothetical protein AlphaFold + ColabFold – – 0.613 No Hit 0.0% —
2508 KP13_08392 Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase arnC AlphaFold + ColabFold –
GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0016780Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. +14 total
0.612 Hit 34.6% 1.14e-10
2509 KP13_05186 AraC family transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.612 No Hit 0.0% —
2510 KP13_03079 F-type conjugal transfer protein TraC ColabFold – – 0.612 No Hit 0.0% —
2511 KP13_03004 hypothetical protein AlphaFold + ColabFold – – 0.612 No Hit 0.0% —
2512 KP13_01796 Ribonuclease HII rnhB AlphaFold + ColabFold
3.1.26.4
GO:0003676Binding to a nucleic acid. GO:0004523Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. GO:0003723Binding to an RNA molecule or a portion thereof. +58 total
0.612 No Hit 0.0% —
2513 KP13_01286 HTH-type transcriptional regulator treR treR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
0.612 No Hit 0.0% —
2514 KP13_01156 hypothetical protein AlphaFold + ColabFold – – 0.612 No Hit 0.0% —
2515 KP13_32162 p-hydroxybenzoate hydroxylase pobA AlphaFold + ColabFold
1.14.13.2
GO:0043639The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0018659Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O. +14 total
0.611 No Hit 0.0% —
2516 KP13_05019 hypothetical protein AlphaFold + ColabFold – – 0.611 No Hit 0.0% —
2517 KP13_02002 Right origin-binding protein rob AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.611 No Hit 0.0% —
2518 KP13_01842 General secretion pathway protein I pulI AlphaFold + ColabFold –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.611 No Hit 0.0% —
2519 KP13_01287 Magnesium-transporting ATPase, P-type 1 mgtA AlphaFold + ColabFold
7.2.2.14
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015693The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015444Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). +69 total
0.611 Hit 38.9% 1.14e-08
2520 KP13_00927 putative arylsulfatase regulator AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +25 total
0.611 No Hit 0.0% —
2521 KP13_00192 putative glycosyltransferase in waa region AlphaFold + ColabFold –
GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
0.611 Hit 33.0% 2.85e-09
2522 KP13_31754 putative oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
0.61 Hit 29.5% 2.44e-13
2523 KP13_04796 hypothetical protein ColabFold – – 0.61 No Hit 0.0% —
2524 KP13_04034 Gp16 phage protein AlphaFold + ColabFold – – 0.61 No Hit 0.0% —
2525 KP13_02845 Glycerol dehydrogenase dhaD AlphaFold + ColabFold
1.1.1.6
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0046872Binding to a metal ion. +47 total
0.61 No Hit 0.0% —
Page of 234 · 5842 total proteins