Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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701 / 5572 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
251 PA2901 hypothetical protein PA2901 Experimental + AlphaFold DB model – – No map 0.788 No Hit N/A —
252 PA2624 isocitrate dehydrogenase PA2624, idh Experimental + AlphaFold DB model
1.1.1.42
GO:0004450Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. GO:0046872Binding to a metal ion. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +25 total
No map 0.788 No Hit N/A —
253 PA1030 hypothetical protein PA1030 Experimental + AlphaFold DB model – – No map 0.787 No Hit N/A —
254 PA0928 sensor/response regulator hybrid protein PA0928, gacS Experimental + AlphaFold DB model
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +811 total
No map 0.787 No Hit N/A —
255 PA3155 UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase wbpE, PA3155 Experimental + AlphaFold DB model
2.6.1.98
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +58 total
No map 0.786 No Hit N/A —
256 PA2305 protein AmbB PA2305, ambB Experimental + AlphaFold DB model
6.2.1.67
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009366A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway. +58 total
No map 0.786 Hit 33.6% 1.33e-12
257 PA1898 quorum-sensing control repressor PA1898, qscR, phzR, sdiA_2 Experimental + AlphaFold DB model –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +47 total
No map 0.786 No Hit N/A —
258 PA2237 biofilm formation protein PslG PA2237, pslG Experimental + AlphaFold DB model –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. GO:0071704OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
No map 0.785 No Hit N/A —
259 PA3388 S-adenosylmethionine-dependent methyltransferase RcsF PA3388, rcsF Experimental + AlphaFold DB model
2.1.1.-
GO:0089715Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.783 Hit 46.3% 6.84e-38
260 PA2086 epoxide hydrolase PA2086 Experimental + AlphaFold DB model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
No map 0.783 Hit 34.9% 8.40e-13
261 PA1000 thioesterase PqsE pqsE, PA1000 Experimental + AlphaFold DB model
3.1.2.32
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0044550The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
No map 0.783 No Hit N/A —
262 PA5259 uroporphyrinogen-III synthase PA5259, hemD Experimental + AlphaFold DB model
4.2.1.75
GO:0004852Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III. GO:0006782The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. GO:0006780The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. +14 total
No map 0.782 No Hit N/A —
263 PA4217 hypothetical protein PA4217, phzS Experimental + AlphaFold DB model
1.14.13.218
GO:0102169Catalysis of the reaction: 5-methyl-phenazine-1-carboxylate + 2 H+ + NADH + O2 = CO2 + H2O + NAD+ + pyocyanin. Also converts phenazine-1-carboxylate into 1-hydroxyphenazine. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
No map 0.782 No Hit N/A —
264 PA5202 hypothetical protein PA5202 Experimental + AlphaFold DB model –
GO:0016289Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+. GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
No map 0.781 No Hit N/A —
265 PA0115 hypothetical protein PA0115 Experimental + AlphaFold DB model –
GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.779 No Hit N/A —
266 PA3540 GDP-mannose 6-dehydrogenase AlgD algD, PA3540 Experimental + AlphaFold DB model
1.1.1.132
GO:0047919Catalysis of the reaction: GDP-alpha-D-mannose + H2O + 2 NAD+ = GDP-D-mannuronate + 3 H+ + 2 NADH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0042121The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). +47 total
No map 0.778 Hit 33.9% 1.84e-08
267 PA2856 esterase TesA tesA, PA2856 Experimental + AlphaFold DB model
3.1.1.1
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0004064Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. GO:0106435Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+. +14 total
No map 0.778 No Hit N/A —
268 PA1403 transcriptional regulator PA1403 Experimental + AlphaFold DB model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.778 No Hit N/A —
269 PA0018 methionyl-tRNA formyltransferase PA0018, fmt Experimental + AlphaFold DB model
2.1.2.9
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004479Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. GO:0071951The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet). +25 total
No map 0.778 Hit 32.3% 3.08e-14
270 PA3992 hypothetical protein PA3992 Experimental + AlphaFold DB model –
GO:0046872Binding to a metal ion. GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +14 total
No map 0.777 No Hit N/A —
271 PA0299 aminotransferase PA0299, spuC Experimental + AlphaFold DB model
2.6.1.113
GO:0004015Catalysis of the reaction: (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = S-adenosyl-4-methylsulfanyl-2-oxobutanoate + (7R,8S)-7,8-diammoniononanoate. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +47 total
No map 0.777 Hit 45.2% 5.88e-06
272 PA5171 arginine deiminase arcA, PA5171 Experimental + AlphaFold DB model
3.5.3.6
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016990Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH4+. GO:0019546OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase. +14 total
No map 0.773 No Hit N/A —
273 PA4959 protein FimX fimX, PA4959 Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:0042802Binding to an identical protein or proteins. +58 total
No map 0.773 No Hit N/A —
274 PA0666 anhydro-N-acetylmuramic acid kinase anmK, PA0666 Experimental + AlphaFold DB model
2.7.1.170
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). +47 total
No map 0.773 No Hit N/A —
275 PA1024 nitronate monooxygenase PA1024 Experimental + AlphaFold DB model
1.6.5.9
GO:0050136Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. GO:0018580Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +14 total
No map 0.772 No Hit N/A —
Page of 29 · 701 total proteins